Qing2ming
2022-01-11
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United Therapeutics, Kiniksa take off on pig-to-human heart transplant<blockquote>United Therapeutics和Kiniksa在猪对人心脏移植方面取得成功</blockquote>
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He's doing well three days after the highly experimental surgery - and is being monitored for immune system problems and other complications - but it's still too early to tell if the operation will work. Due to his condition, Bennett had also received a pig heart valve about a decade ago, which (along with pig skin grafts) are routinely used in humans.</p><p><blockquote><html><head></head><body>为了挽救他的生命，马里兰大学医学中心的医生将一颗转基因猪心脏移植到了来自马里兰州的57岁勤杂工大卫·贝内特身上。经过高度实验性的手术三天后，他的情况很好，正在接受免疫系统问题和其他并发症的监测，但现在判断手术是否有效还为时过早。由于他的病情，贝内特在大约十年前还接受了猪心脏瓣膜，该瓣膜（与猪皮肤移植物一起）通常用于人类。</body></html></blockquote></p><p>Snapshot: "It was either die or do this transplant. I want to live. I know it's a shot in the dark, but it's my last choice," Bennett said a day before the nine-hour surgery. While he knew there was no guarantee the experiment would be effective, Bennett was ineligible for a human heart transplant or pump due to heart failure condition and an irregular heartbeat. The FDA, which oversees such experiments, allowed the xenotransplantation surgery under "compassionate use" emergency authorization, which is available when a patient with a life-threatening condition has no other options.</p><p><blockquote>快照：“要么死，要么做移植手术。我想活下去。我知道这是瞎猜，但这是我最后的选择，”贝内特在九个小时的手术前一天说。虽然贝内特知道不能保证实验会有效，但由于心力衰竭和心跳不规则，他没有资格接受人类心脏移植或泵。监督此类实验的FDA允许在“同情使用”紧急授权下进行异种移植手术，当患有危及生命疾病的患者没有其他选择时，可以使用这种授权。</blockquote></p><p>"If this works, there will be an endless supply of these organs for patients who are suffering," said Dr. Muhammad Mohiuddin, scientific director of the University of Maryland's animal-to-human transplant program. A total of 106,657 people are currently on the national transplant waiting list, and more than 6,200 patients die each year before getting one. More than 40,000 organ transplants were done in the U.S. in 2021, including a record 3,800 heart transplants.</p><p><blockquote>马里兰大学动物到人类移植项目的科学主任穆罕默德·莫希丁博士说：“如果这有效，这些器官将源源不断地供应给遭受痛苦的患者。”目前共有106,657人在国家移植等候名单上，每年有超过6,200名患者在接受移植之前死亡。2021年，美国进行了超过40,000例器官移植，其中包括创纪录的3,800例心脏移植。</blockquote></p><p>New gene editing tools: Several biotech companies are developing pig organs for human transplant, with the heart used in the most recent operation coming from Revivicor, a subsidiary of <a href=\"https://laohu8.com/S/UTHR\">United Therapeutics </a>. The organ was modified to make it more acceptable to a human, including removing and inserting 10 genes to keep the heart from growing after transplant among other changes. The team at the University of Maryland Medical Center also used a new drug made by <a href=\"https://laohu8.com/S/KNSA\">Kiniksa Pharmaceuticals </a> to help prevent the organ from being rejected by the patient.</p><p><blockquote>新的基因编辑工具：几家生物技术公司正在开发用于人体移植的猪器官，最近一次手术中使用的心脏来自Revivicor，该公司是<a href=\"https://laohu8.com/S/UTHR\">联合治疗公司</a>该器官被修改以使其更容易被人类接受，包括移除和插入10个基因以防止心脏在移植后生长以及其他变化。马里兰大学医学中心的团队还使用了一种由<a href=\"https://laohu8.com/S/KNSA\">Kiniksa制药</a>以帮助防止器官被患者排斥。</blockquote></p><p></body></html></p><p><blockquote></blockquote></p><p></p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>United Therapeutics, Kiniksa take off on pig-to-human heart transplant<blockquote>United Therapeutics和Kiniksa在猪对人心脏移植方面取得成功</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nUnited Therapeutics, Kiniksa take off on pig-to-human heart transplant<blockquote>United Therapeutics和Kiniksa在猪对人心脏移植方面取得成功</blockquote>\n</h2>\n<h4 class=\"meta\">\n<p class=\"head\">\n<strong class=\"h-name small\">Seeking Alpha</strong><span class=\"h-time small\">2022-01-11 18:02</span>\n</p>\n</h4>\n</header>\n<article>\n<p><html><head></head><body>In a last-ditch effort to save his life, doctors at the University of Maryland Medical Center have transplanted a genetically modified pig heart into patient David Bennett, a 57-year-old handyman from Maryland. He's doing well three days after the highly experimental surgery - and is being monitored for immune system problems and other complications - but it's still too early to tell if the operation will work. Due to his condition, Bennett had also received a pig heart valve about a decade ago, which (along with pig skin grafts) are routinely used in humans.</p><p><blockquote><html><head></head><body>为了挽救他的生命，马里兰大学医学中心的医生将一颗转基因猪心脏移植到了来自马里兰州的57岁勤杂工大卫·贝内特身上。经过高度实验性的手术三天后，他的情况很好，正在接受免疫系统问题和其他并发症的监测，但现在判断手术是否有效还为时过早。由于他的病情，贝内特在大约十年前还接受了猪心脏瓣膜，该瓣膜（与猪皮肤移植物一起）通常用于人类。</body></html></blockquote></p><p>Snapshot: "It was either die or do this transplant. I want to live. I know it's a shot in the dark, but it's my last choice," Bennett said a day before the nine-hour surgery. While he knew there was no guarantee the experiment would be effective, Bennett was ineligible for a human heart transplant or pump due to heart failure condition and an irregular heartbeat. The FDA, which oversees such experiments, allowed the xenotransplantation surgery under "compassionate use" emergency authorization, which is available when a patient with a life-threatening condition has no other options.</p><p><blockquote>快照：“要么死，要么做移植手术。我想活下去。我知道这是瞎猜，但这是我最后的选择，”贝内特在九个小时的手术前一天说。虽然贝内特知道不能保证实验会有效，但由于心力衰竭和心跳不规则，他没有资格接受人类心脏移植或泵。监督此类实验的FDA允许在“同情使用”紧急授权下进行异种移植手术，当患有危及生命疾病的患者没有其他选择时，可以使用这种授权。</blockquote></p><p>"If this works, there will be an endless supply of these organs for patients who are suffering," said Dr. Muhammad Mohiuddin, scientific director of the University of Maryland's animal-to-human transplant program. A total of 106,657 people are currently on the national transplant waiting list, and more than 6,200 patients die each year before getting one. More than 40,000 organ transplants were done in the U.S. in 2021, including a record 3,800 heart transplants.</p><p><blockquote>马里兰大学动物到人类移植项目的科学主任穆罕默德·莫希丁博士说：“如果这有效，这些器官将源源不断地供应给遭受痛苦的患者。”目前共有106,657人在国家移植等候名单上，每年有超过6,200名患者在接受移植之前死亡。2021年，美国进行了超过40,000例器官移植，其中包括创纪录的3,800例心脏移植。</blockquote></p><p>New gene editing tools: Several biotech companies are developing pig organs for human transplant, with the heart used in the most recent operation coming from Revivicor, a subsidiary of <a href=\"https://laohu8.com/S/UTHR\">United Therapeutics </a>. The organ was modified to make it more acceptable to a human, including removing and inserting 10 genes to keep the heart from growing after transplant among other changes. The team at the University of Maryland Medical Center also used a new drug made by <a href=\"https://laohu8.com/S/KNSA\">Kiniksa Pharmaceuticals </a> to help prevent the organ from being rejected by the patient.</p><p><blockquote>新的基因编辑工具：几家生物技术公司正在开发用于人体移植的猪器官，最近一次手术中使用的心脏来自Revivicor，该公司是<a href=\"https://laohu8.com/S/UTHR\">联合治疗公司</a>该器官被修改以使其更容易被人类接受，包括移除和插入10个基因以防止心脏在移植后生长以及其他变化。马里兰大学医学中心的团队还使用了一种由<a href=\"https://laohu8.com/S/KNSA\">Kiniksa制药</a>以帮助防止器官被患者排斥。</blockquote></p><p></body></html></p><p><blockquote></blockquote></p><p></p>\n<div class=\"bt-text\">\n\n\n<p> 来源：<a href=\"https://seekingalpha.com/news/3786925-united-therapeutics-kiniksa-take-off-on-pig-to-human-heart-transplant\">Seeking Alpha</a></p>\n<p>为提升您的阅读体验，我们对本页面进行了排版优化</p>\n\n\n</div>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"UTHR":"美国联合医疗","KNSA":"Kiniksa Pharmaceuticals Ltd."},"source_url":"https://seekingalpha.com/news/3786925-united-therapeutics-kiniksa-take-off-on-pig-to-human-heart-transplant","is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1194794619","content_text":"In a last-ditch effort to save his life, doctors at the University of Maryland Medical Center have transplanted a genetically modified pig heart into patient David Bennett, a 57-year-old handyman from Maryland. He's doing well three days after the highly experimental surgery - and is being monitored for immune system problems and other complications - but it's still too early to tell if the operation will work. Due to his condition, Bennett had also received a pig heart valve about a decade ago, which (along with pig skin grafts) are routinely used in humans.Snapshot: \"It was either die or do this transplant. I want to live. I know it's a shot in the dark, but it's my last choice,\" Bennett said a day before the nine-hour surgery. While he knew there was no guarantee the experiment would be effective, Bennett was ineligible for a human heart transplant or pump due to heart failure condition and an irregular heartbeat. The FDA, which oversees such experiments, allowed the xenotransplantation surgery under \"compassionate use\" emergency authorization, which is available when a patient with a life-threatening condition has no other options.\"If this works, there will be an endless supply of these organs for patients who are suffering,\" said Dr. Muhammad Mohiuddin, scientific director of the University of Maryland's animal-to-human transplant program. A total of 106,657 people are currently on the national transplant waiting list, and more than 6,200 patients die each year before getting one. More than 40,000 organ transplants were done in the U.S. in 2021, including a record 3,800 heart transplants.New gene editing tools: Several biotech companies are developing pig organs for human transplant, with the heart used in the most recent operation coming from Revivicor, a subsidiary of United Therapeutics . The organ was modified to make it more acceptable to a human, including removing and inserting 10 genes to keep the heart from growing after transplant among other changes. The team at the University of Maryland Medical Center also used a new drug made by Kiniksa Pharmaceuticals to help prevent the organ from being rejected by the patient.","news_type":1,"symbols_score_info":{"UTHR":0.9,"KNSA":0.9}},"isVote":1,"tweetType":1,"viewCount":1683,"commentLimit":10,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"symbols":[],"verified":2,"subType":0,"readableState":1,"langContent":"CN","currentLanguage":"CN","warmUpFlag":false,"orderFlag":false,"shareable":true,"causeOfNotShareable":"","featuresForAnalytics":[],"commentAndTweetFlag":false,"andRepostAutoSelectedFlag":false,"upFlag":false,"length":4,"xxTargetLangEnum":"ZH_CN"},"commentList":[],"isCommentEnd":true,"isTiger":false,"isWeiXinMini":false,"url":"/m/post/694860957"}
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