Qing2ming
2022-01-11
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United Therapeutics, Kiniksa take off on pig-to-human heart transplant<blockquote>United Therapeutics 和 Kiniksa 在猪到人的心脏移植方面起飞</blockquote>
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He's doing well three days after the highly experimental surgery - and is being monitored for immune system problems and other complications - but it's still too early to tell if the operation will work. Due to his condition, Bennett had also received a pig heart valve about a decade ago, which (along with pig skin grafts) are routinely used in humans.</p><p><blockquote><html><head></head><body>为了挽救他的生命，马里兰大学医学中心的医生将一颗转基因猪心脏移植到了来自马里兰州的 57 岁杂工大卫·贝内特体内。在极具实验性的手术三天后，他表现良好，正在接受免疫系统问题和其他并发症的监测，但现在判断手术是否有效还为时过早。由于他的病情，贝内特大约十年前还接受了猪心脏瓣膜，这种瓣膜（连同猪皮移植物）通常用于人类。</body></html></blockquote></p><p>Snapshot: "It was either die or do this transplant. I want to live. I know it's a shot in the dark, but it's my last choice," Bennett said a day before the nine-hour surgery. While he knew there was no guarantee the experiment would be effective, Bennett was ineligible for a human heart transplant or pump due to heart failure condition and an irregular heartbeat. The FDA, which oversees such experiments, allowed the xenotransplantation surgery under "compassionate use" emergency authorization, which is available when a patient with a life-threatening condition has no other options.</p><p><blockquote>快照：“要么死，要么做移植手术。我想活下去。我知道这是一个在黑暗中拍摄的机会，但这是我最后的选择，”贝内特在九个小时的手术前一天说。虽然他知道不能保证实验会有效，但由于心力衰竭和心律不齐，贝内特没有资格进行人类心脏移植或泵血。负责监督此类实验的 FDA 允许在“同情使用”紧急授权下进行异种移植手术，当患有危及生命疾病的患者别无选择时，该授权可以使用。</blockquote></p><p>"If this works, there will be an endless supply of these organs for patients who are suffering," said Dr. Muhammad Mohiuddin, scientific director of the University of Maryland's animal-to-human transplant program. A total of 106,657 people are currently on the national transplant waiting list, and more than 6,200 patients die each year before getting one. More than 40,000 organ transplants were done in the U.S. in 2021, including a record 3,800 heart transplants.</p><p><blockquote>马里兰大学动物到人类移植项目科学主任穆罕默德·莫希丁博士说：“如果这种方法奏效，这些器官将源源不断地供应给遭受痛苦的患者。”目前共有106,657人在全国移植等待名单上，每年有超过6,200名患者在接受移植前死亡。2021 年，美国进行了超过 40,000 例器官移植，其中包括创纪录的 3,800 例心脏移植。</blockquote></p><p>New gene editing tools: Several biotech companies are developing pig organs for human transplant, with the heart used in the most recent operation coming from Revivicor, a subsidiary of <a href=\"https://laohu8.com/S/UTHR\">United Therapeutics </a>. The organ was modified to make it more acceptable to a human, including removing and inserting 10 genes to keep the heart from growing after transplant among other changes. The team at the University of Maryland Medical Center also used a new drug made by <a href=\"https://laohu8.com/S/KNSA\">Kiniksa Pharmaceuticals </a> to help prevent the organ from being rejected by the patient.</p><p><blockquote>新的基因编辑工具：几家生物技术公司正在开发用于人体移植的猪器官，最近一次手术中使用的心脏来自Revivicor的子公司<a href=\"https://laohu8.com/S/UTHR\">联合疗法</a>该器官经过改造，使其更容易被人类接受，包括移除和插入10个基因，以防止心脏移植后心脏生长，以及其他改变。马里兰大学医学中心的研究小组还使用了一种由<a href=\"https://laohu8.com/S/KNSA\">基尼克萨制药</a>以帮助防止器官被患者排斥。</blockquote></p><p></body></html></p><p><blockquote></blockquote></p><p></p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>United Therapeutics, Kiniksa take off on pig-to-human heart transplant<blockquote>United Therapeutics 和 Kiniksa 在猪到人的心脏移植方面起飞</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nUnited Therapeutics, Kiniksa take off on pig-to-human heart transplant<blockquote>United Therapeutics 和 Kiniksa 在猪到人的心脏移植方面起飞</blockquote>\n</h2>\n<h4 class=\"meta\">\n<p class=\"head\">\n<strong class=\"h-name small\">Seeking Alpha</strong><span class=\"h-time small\">2022-01-11 18:02</span>\n</p>\n</h4>\n</header>\n<article>\n<p><html><head></head><body>In a last-ditch effort to save his life, doctors at the University of Maryland Medical Center have transplanted a genetically modified pig heart into patient David Bennett, a 57-year-old handyman from Maryland. He's doing well three days after the highly experimental surgery - and is being monitored for immune system problems and other complications - but it's still too early to tell if the operation will work. Due to his condition, Bennett had also received a pig heart valve about a decade ago, which (along with pig skin grafts) are routinely used in humans.</p><p><blockquote><html><head></head><body>为了挽救他的生命，马里兰大学医学中心的医生将一颗转基因猪心脏移植到了来自马里兰州的 57 岁杂工大卫·贝内特体内。在极具实验性的手术三天后，他表现良好，正在接受免疫系统问题和其他并发症的监测，但现在判断手术是否有效还为时过早。由于他的病情，贝内特大约十年前还接受了猪心脏瓣膜，这种瓣膜（连同猪皮移植物）通常用于人类。</body></html></blockquote></p><p>Snapshot: "It was either die or do this transplant. I want to live. I know it's a shot in the dark, but it's my last choice," Bennett said a day before the nine-hour surgery. While he knew there was no guarantee the experiment would be effective, Bennett was ineligible for a human heart transplant or pump due to heart failure condition and an irregular heartbeat. The FDA, which oversees such experiments, allowed the xenotransplantation surgery under "compassionate use" emergency authorization, which is available when a patient with a life-threatening condition has no other options.</p><p><blockquote>快照：“要么死，要么做移植手术。我想活下去。我知道这是一个在黑暗中拍摄的机会，但这是我最后的选择，”贝内特在九个小时的手术前一天说。虽然他知道不能保证实验会有效，但由于心力衰竭和心律不齐，贝内特没有资格进行人类心脏移植或泵血。负责监督此类实验的 FDA 允许在“同情使用”紧急授权下进行异种移植手术，当患有危及生命疾病的患者别无选择时，该授权可以使用。</blockquote></p><p>"If this works, there will be an endless supply of these organs for patients who are suffering," said Dr. Muhammad Mohiuddin, scientific director of the University of Maryland's animal-to-human transplant program. A total of 106,657 people are currently on the national transplant waiting list, and more than 6,200 patients die each year before getting one. More than 40,000 organ transplants were done in the U.S. in 2021, including a record 3,800 heart transplants.</p><p><blockquote>马里兰大学动物到人类移植项目科学主任穆罕默德·莫希丁博士说：“如果这种方法奏效，这些器官将源源不断地供应给遭受痛苦的患者。”目前共有106,657人在全国移植等待名单上，每年有超过6,200名患者在接受移植前死亡。2021 年，美国进行了超过 40,000 例器官移植，其中包括创纪录的 3,800 例心脏移植。</blockquote></p><p>New gene editing tools: Several biotech companies are developing pig organs for human transplant, with the heart used in the most recent operation coming from Revivicor, a subsidiary of <a href=\"https://laohu8.com/S/UTHR\">United Therapeutics </a>. The organ was modified to make it more acceptable to a human, including removing and inserting 10 genes to keep the heart from growing after transplant among other changes. The team at the University of Maryland Medical Center also used a new drug made by <a href=\"https://laohu8.com/S/KNSA\">Kiniksa Pharmaceuticals </a> to help prevent the organ from being rejected by the patient.</p><p><blockquote>新的基因编辑工具：几家生物技术公司正在开发用于人体移植的猪器官，最近一次手术中使用的心脏来自Revivicor的子公司<a href=\"https://laohu8.com/S/UTHR\">联合疗法</a>该器官经过改造，使其更容易被人类接受，包括移除和插入10个基因，以防止心脏移植后心脏生长，以及其他改变。马里兰大学医学中心的研究小组还使用了一种由<a href=\"https://laohu8.com/S/KNSA\">基尼克萨制药</a>以帮助防止器官被患者排斥。</blockquote></p><p></body></html></p><p><blockquote></blockquote></p><p></p>\n<div class=\"bt-text\">\n\n\n<p> 来源：<a href=\"https://seekingalpha.com/news/3786925-united-therapeutics-kiniksa-take-off-on-pig-to-human-heart-transplant\">Seeking Alpha</a></p>\n<p>为提升您的阅读体验，我们对本页面进行了排版优化</p>\n\n\n</div>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"UTHR":"美国联合医疗","KNSA":"Kiniksa Pharmaceuticals Ltd."},"source_url":"https://seekingalpha.com/news/3786925-united-therapeutics-kiniksa-take-off-on-pig-to-human-heart-transplant","is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1194794619","content_text":"In a last-ditch effort to save his life, doctors at the University of Maryland Medical Center have transplanted a genetically modified pig heart into patient David Bennett, a 57-year-old handyman from Maryland. He's doing well three days after the highly experimental surgery - and is being monitored for immune system problems and other complications - but it's still too early to tell if the operation will work. Due to his condition, Bennett had also received a pig heart valve about a decade ago, which (along with pig skin grafts) are routinely used in humans.Snapshot: \"It was either die or do this transplant. I want to live. I know it's a shot in the dark, but it's my last choice,\" Bennett said a day before the nine-hour surgery. While he knew there was no guarantee the experiment would be effective, Bennett was ineligible for a human heart transplant or pump due to heart failure condition and an irregular heartbeat. The FDA, which oversees such experiments, allowed the xenotransplantation surgery under \"compassionate use\" emergency authorization, which is available when a patient with a life-threatening condition has no other options.\"If this works, there will be an endless supply of these organs for patients who are suffering,\" said Dr. Muhammad Mohiuddin, scientific director of the University of Maryland's animal-to-human transplant program. A total of 106,657 people are currently on the national transplant waiting list, and more than 6,200 patients die each year before getting one. More than 40,000 organ transplants were done in the U.S. in 2021, including a record 3,800 heart transplants.New gene editing tools: Several biotech companies are developing pig organs for human transplant, with the heart used in the most recent operation coming from Revivicor, a subsidiary of United Therapeutics . The organ was modified to make it more acceptable to a human, including removing and inserting 10 genes to keep the heart from growing after transplant among other changes. The team at the University of Maryland Medical Center also used a new drug made by Kiniksa Pharmaceuticals to help prevent the organ from being rejected by the patient.","news_type":1,"symbols_score_info":{"UTHR":0.9,"KNSA":0.9}},"isVote":1,"tweetType":1,"viewCount":2340,"commentLimit":10,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"symbols":[],"verified":2,"subType":0,"readableState":1,"langContent":"CN","currentLanguage":"CN","warmUpFlag":false,"orderFlag":false,"shareable":true,"causeOfNotShareable":"","featuresForAnalytics":[],"commentAndTweetFlag":false,"andRepostAutoSelectedFlag":false,"upFlag":false,"length":4,"subscribersOnly":false,"subscribersOnlyAccessible":false,"xxTargetLangEnum":"ZH_CN"},"commentList":[],"isCommentEnd":true,"isTiger":false,"isWeiXinMini":false,"url":"/m/post/694860957"}
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