JiaLe
2021-08-31
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AC Immune shares surged more than 70% in early trading<blockquote>AC Immune股价早盘飙升70%以上</blockquote>
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The second co-primary endpoint, ADCS-ADL (functional scale), was not met.</li> <li>Safety data showed that semorinemab was well tolerated with an acceptable safety profile and no unanticipated safety signals.</li> <li>Semorinemab demonstrated a statistically significant reduction in cognitive decline from baseline by 43.6% compared to placebo at week 49.</li> <li>There was no effect on the other co-primary endpoint of reducing the rate of functional decline. Genentech has reported that the open-label portion of the study will continue as planned.</li> <li>Further analyses are ongoing, and the company will submit topline data for presentation at the CTAD conference in November.</li> <li>Semorinemab is an investigational monoclonal anti-tau antibody that targets the N-terminal portion of the tau protein and is designed to bind to tau and slow its spread between neurons.</li> </ul></p><p><blockquote><ul><li><b>交流免疫SA</b>及其合作伙伴<b>基因泰克</b>，的一部分<b>罗氏控股公司</b>公布了评估semorinemab治疗轻度至中度阿尔茨海默病（AD）的2期研究的主要数据。</li><li>Semorinemab符合其共同主要终点之一ADAS-Cog11（认知量表）。第二个共同主要终点ADCS-ADL（功能量表）未达到。</li><li>安全性数据显示，semorinemab耐受性良好，安全性特征可接受，无意外安全性信号。</li><li>在第49周时，与安慰剂相比，Semorinemab显示认知能力下降较基线降低了43.6%，具有统计学意义。</li><li>对降低功能衰退率的另一个共同主要终点没有影响。基因泰克报告称，该研究的开放标签部分将按计划继续进行。</li><li>进一步的分析正在进行中，该公司将提交主要数据，以便在 11 月的 CTAD 会议上进行展示。</li><li>Semorinemab是一种研究性单克隆抗tau抗体，靶向tau蛋白的N-末端部分，旨在结合tau并减缓其在神经元之间的扩散。</li></ul></blockquote></p><p></p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>AC Immune shares surged more than 70% in early trading<blockquote>AC Immune股价早盘飙升70%以上</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; 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overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nAC Immune shares surged more than 70% in early trading<blockquote>AC Immune股价早盘飙升70%以上</blockquote>\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/1079075236\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Tiger Newspress </p>\n<p class=\"h-time smaller\">2021-08-31 21:41</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<p>AC Immune shares surged more than 70% in early trading.</p><p><blockquote>AC Immune 股价早盘飙升超过 70%。</blockquote></p><p> <img src=\"https://static.tigerbbs.com/9e1ae2e20dee3043b692297f3834cf6d\" tg-width=\"878\" tg-height=\"616\" referrerpolicy=\"no-referrer\"></p><p><blockquote></blockquote></p><p> <ul> <li><b>AC Immune SA</b> and its collaborating partner <b>Genentech</b>, part of <b>Roche Holdings AG</b>, have announced topline data from Phase 2 study evaluating semorinemab in mild-to-moderate Alzheimer's disease (AD).</li> <li>Semorinemab met one of its co-primary endpoints, ADAS-Cog11 (cognitive scale). The second co-primary endpoint, ADCS-ADL (functional scale), was not met.</li> <li>Safety data showed that semorinemab was well tolerated with an acceptable safety profile and no unanticipated safety signals.</li> <li>Semorinemab demonstrated a statistically significant reduction in cognitive decline from baseline by 43.6% compared to placebo at week 49.</li> <li>There was no effect on the other co-primary endpoint of reducing the rate of functional decline. Genentech has reported that the open-label portion of the study will continue as planned.</li> <li>Further analyses are ongoing, and the company will submit topline data for presentation at the CTAD conference in November.</li> <li>Semorinemab is an investigational monoclonal anti-tau antibody that targets the N-terminal portion of the tau protein and is designed to bind to tau and slow its spread between neurons.</li> </ul></p><p><blockquote><ul><li><b>交流免疫SA</b>及其合作伙伴<b>基因泰克</b>，的一部分<b>罗氏控股公司</b>公布了评估semorinemab治疗轻度至中度阿尔茨海默病（AD）的2期研究的主要数据。</li><li>Semorinemab符合其共同主要终点之一ADAS-Cog11（认知量表）。第二个共同主要终点ADCS-ADL（功能量表）未达到。</li><li>安全性数据显示，semorinemab耐受性良好，安全性特征可接受，无意外安全性信号。</li><li>在第49周时，与安慰剂相比，Semorinemab显示认知能力下降较基线降低了43.6%，具有统计学意义。</li><li>对降低功能衰退率的另一个共同主要终点没有影响。基因泰克报告称，该研究的开放标签部分将按计划继续进行。</li><li>进一步的分析正在进行中，该公司将提交主要数据，以便在 11 月的 CTAD 会议上进行展示。</li><li>Semorinemab是一种研究性单克隆抗tau抗体，靶向tau蛋白的N-末端部分，旨在结合tau并减缓其在神经元之间的扩散。</li></ul></blockquote></p><p></p>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"ACIU":"AC Immune SA"},"is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1174676883","content_text":"AC Immune shares surged more than 70% in early trading.\n\n\nAC Immune SA and its collaborating partner Genentech, part of Roche Holdings AG, have announced topline data from Phase 2 study evaluating semorinemab in mild-to-moderate Alzheimer's disease (AD).\nSemorinemab met one of its co-primary endpoints, ADAS-Cog11 (cognitive scale). The second co-primary endpoint, ADCS-ADL (functional scale), was not met.\nSafety data showed that semorinemab was well tolerated with an acceptable safety profile and no unanticipated safety signals.\nSemorinemab demonstrated a statistically significant reduction in cognitive decline from baseline by 43.6% compared to placebo at week 49.\nThere was no effect on the other co-primary endpoint of reducing the rate of functional decline. Genentech has reported that the open-label portion of the study will continue as planned.\nFurther analyses are ongoing, and the company will submit topline data for presentation at the CTAD conference in November.\nSemorinemab is an investigational monoclonal anti-tau antibody that targets the N-terminal portion of the tau protein and is designed to bind to tau and slow its spread between neurons.","news_type":1,"symbols_score_info":{"ACIU":0.9}},"isVote":1,"tweetType":1,"viewCount":722,"commentLimit":10,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"symbols":[],"verified":2,"subType":0,"readableState":1,"langContent":"EN","currentLanguage":"EN","warmUpFlag":false,"orderFlag":false,"shareable":true,"causeOfNotShareable":"","featuresForAnalytics":[],"commentAndTweetFlag":false,"andRepostAutoSelectedFlag":false,"upFlag":false,"length":12,"subscribersOnly":false,"subscribersOnlyAccessible":false,"xxTargetLangEnum":"ORIG"},"commentList":[],"isCommentEnd":true,"isTiger":false,"isWeiXinMini":false,"url":"/m/post/818504749"}
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