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Charis4455
2021-12-15
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Upstart Shares Have Plunged, But Stay Away for Now<blockquote>Upstart股价暴跌，但暂时远离</blockquote>
Charis4455
2021-12-01
Huatz
Merck shares jumped 5.3% in premarket trading<blockquote>默克股价在盘前交易中上涨5.3%</blockquote>
Charis4455
2021-11-13
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10:09","market":"us","language":"en","title":"Upstart Shares Have Plunged, But Stay Away for Now<blockquote>Upstart股价暴跌，但暂时远离</blockquote>","url":"https://stock-news.laohu8.com/highlight/detail?id=1180160205","media":"InvestorPlace","summary":"Even after crashing, UPST stock remains risky","content":"<p><div> Upstart (NASDAQ:UPST) has been one of this year’s top performers. Shares of UPST stock are up over 250% year-to-date (YTD), from around $40 at the start of 2021 to $145 as of the close of Dec. 14. You...</p><p><blockquote><div>Upstart（纳斯达克股票代码：UPST）是今年表现最好的公司之一。UPST股票今年迄今(YTD)上涨了250%以上，从2021年初的40美元左右上涨至12月14日收盘的145美元。你...</div></blockquote></p><p> <a href=\"https://investorplace.com/2021/12/upst-stock-has-plunged-but-stay-away-from-shares-for-now/\">网页链接</a> </div> </p><p><blockquote><a href=\"https://investorplace.com/2021/12/upst-stock-has-plunged-but-stay-away-from-shares-for-now/\">网页连接</a></blockquote></p><p></p>","source":"lsy1606302653667","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Upstart Shares Have Plunged, But Stay Away for Now<blockquote>Upstart股价暴跌，但暂时远离</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nUpstart Shares Have Plunged, But Stay Away for Now<blockquote>Upstart股价暴跌，但暂时远离</blockquote>\n</h2>\n<h4 class=\"meta\">\n<p class=\"head\">\n<strong class=\"h-name small\">InvestorPlace</strong><span class=\"h-time small\">2021-12-15 10:09</span>\n</p>\n</h4>\n</header>\n<article>\n<p><div> Upstart (NASDAQ:UPST) has been one of this year’s top performers. Shares of UPST stock are up over 250% year-to-date (YTD), from around $40 at the start of 2021 to $145 as of the close of Dec. 14. You...</p><p><blockquote><div>Upstart（纳斯达克股票代码：UPST）是今年表现最好的公司之一。UPST股票今年迄今(YTD)上涨了250%以上，从2021年初的40美元左右上涨至12月14日收盘的145美元。你...</div></blockquote></p><p> <a href=\"https://investorplace.com/2021/12/upst-stock-has-plunged-but-stay-away-from-shares-for-now/\">网页链接</a> </div> </p><p><blockquote><a href=\"https://investorplace.com/2021/12/upst-stock-has-plunged-but-stay-away-from-shares-for-now/\">网页连接</a></blockquote></p><p></p>\n<div class=\"bt-text\">\n\n\n<p> 来源：<a href=\"https://investorplace.com/2021/12/upst-stock-has-plunged-but-stay-away-from-shares-for-now/\">InvestorPlace</a></p>\n<p>为提升您的阅读体验，我们对本页面进行了排版优化</p>\n\n\n</div>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"UPST":"Upstart Holdings, Inc."},"source_url":"https://investorplace.com/2021/12/upst-stock-has-plunged-but-stay-away-from-shares-for-now/","is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1180160205","content_text":"Upstart (NASDAQ:UPST) has been one of this year’s top performers. Shares of UPST stock are up over 250% year-to-date (YTD), from around $40 at the start of 2021 to $145 as of the close of Dec. 14.\nYou probably wouldn’t realize that if you’ve just tuned into the Upstart story, however. While UPST is up huge on the year, the gains have shrunk dramatically from where they were back in October. At that point, the stock had briefly hit $400 as speculative fervor peaked.\nThe top soon came following an embarrassing interview onCNBC. The business channel had on stock trader Mark Minervini to discuss UPST stock and Minervini talked up the company’s strong technicals and momentum. However, when the CNBC host asked Minervini to explain Upstart’s business model, he froze up. Seemingly unable to answer, Minervini blamed audio issues and the interview abruptly ended.\nThat moment went viral and the UPST stock price soon started to crash. It seems a lot of people, like Minervini, appreciated Upstart primarily because of its strong price performance rather than the company’s actual business. With the momentum in the stock long gone, however, is it time to buy in during this correction?\nUPST Stock: Rapid But Slowing Growth\nAt first glance, Upstart’s third-quarter earnings report didn’t look too bad. The company beat estimates on both the top and bottom line. In particular, the earnings figure was substantially ahead of expectations. Based on that, you might have thought Upstart would rally on the results, or at least hold its ground. Instead, UPST stock immediately plunged 20% upon the Q3 release.\nWhat went wrong? For one thing, investors had their expectations in the stratosphere. Analysts may have had more conservative numbers, but quick money traders were expecting massive growth in Q3 after Q2’s blowout earnings. Instead, Q3 was only moderately ahead of expectations.\nSpecifically, Upstart’s growth rate showed the issues. For the quarter, revenue growth slowed to 18% sequentially versus 60% in Q2. That’s a massive decline. And that came even as some analysts have become concerned that Upstart may be lowering loan quality standards to attract more business. Adding to that point, while the company grew revenues sequentially, the contribution margin actually declined slightly in Q3 versus Q2.\nLong story short, Upstart’s incredible growth phase appears to be drawing to a close. Meanwhile, shares are trading at 100 times this year’s earnings and a projected 77 times forward earnings, according toSeeking Alpha. That’s far too high for a company with rapidly slowing revenue and earnings growth. On top of that, add the fact that it faces substantial cyclical concerns if and when the economy turns downward once again.\nUPST stock completed its initial public offering (IPO) at $20 per share just a year ago. It’s no surprise that the stock is having trouble supporting a price 10 times that high just a year later. Momentum traders got way over their skis on this one.\nAnalysts Also Worry About Valuation\nI’m hardly the only person that’s concerned about Upstart’s valuation, too. For example, Morgan Stanley initiated coverage of Upstart shares last week with a neutral rating.\nMorgan Stanley’s James Faucette did credit the company for its rapid growth. However, Faucette also warned that it has benefitted from unusually favorable credit conditions among other tailwinds. The analyst is monitoring Upstart for incremental changes to the growth story.\nIn the meantime, it’s not exactly encouraging that Faucette assigned UPST stock a neutral rating on shares with the stock already back under $200. Just because this name hit $400 before doesn’t necessarily mean it’s a bargain below $200 per share.\nThe Verdict on Upstart\nThe last time I covered Upstart, I took an unequivocally negative view, warning that it was “overvalued and set to crash.”Indeed, the stock has plunged from $300 to below $160 since that article’s publication. That wasn’t too complicated of a call — there was absolutely no way to justify a valuation anywhere near that level.\nHowever, the investment case now is a little more nuanced with the stock down a quick 50%. At this point, shares are oversold — rather than overbought — on a short-term basis. To some extent, UPST stock has gotten hit with tax loss and momentum-based selling as people that bought at $300 and above sell out of shares to move their capital elsewhere.\nSo, would it be surprising if UPST stock bounces once the calendar flips into 2022? Not at all. Over the longer-term, though, Upstart remains seriously overvalued compared to its medium-term business prospects. The company will need to expand into more lending verticals — without letting credit quality slide — if it’s going to support a triple-digit price going forward.","news_type":1,"symbols_score_info":{"UPST":0.9}},"isVote":1,"tweetType":1,"viewCount":2042,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":603919337,"gmtCreate":1638350710918,"gmtModify":1638350710990,"author":{"id":"3582016082149562","authorId":"3582016082149562","name":"Charis4455","avatar":"https://static.tigerbbs.com/170154e3e4358555276582209b5e7550","crmLevel":11,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3582016082149562","idStr":"3582016082149562"},"themes":[],"htmlText":"Huatz ","listText":"Huatz ","text":"Huatz","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":8,"commentSize":1,"repostSize":0,"link":"https://laohu8.com/post/603919337","repostId":"1116877933","repostType":2,"repost":{"id":"1116877933","kind":"news","weMediaInfo":{"introduction":"Providing stock market headlines, business news, financials and earnings ","home_visible":1,"media_name":"Tiger Newspress","id":"1079075236","head_image":"https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba"},"pubTimestamp":1638350081,"share":"https://www.laohu8.com/m/news/1116877933?lang=zh_CN&edition=full","pubTime":"2021-12-01 17:14","market":"us","language":"en","title":"Merck shares jumped 5.3% in premarket trading<blockquote>默克股价在盘前交易中上涨5.3%</blockquote>","url":"https://stock-news.laohu8.com/highlight/detail?id=1116877933","media":"Tiger Newspress","summary":"Merck shares jumped 5.3% in premarket trading as FDA advisers recommended its COVID-19 pill in close","content":"<p>Merck shares jumped 5.3% in premarket trading as FDA advisers recommended its COVID-19 pill in close vote.</p><p><blockquote>由于FDA顾问以势均力敌的投票推荐其COVID-19药物，默克股价在盘前交易中上涨5.3%。</blockquote></p><p> <img src=\"https://static.tigerbbs.com/52b0f147fff1ac74d32cd5d5643fe2b3\" tg-width=\"850\" tg-height=\"620\" referrerpolicy=\"no-referrer\"></p><p><blockquote></blockquote></p><p> The Food and Drug Administration advisory committee said Tuesday the benefits of Merck & Co.'s experimental antiviral COVID-19 pill outweigh its risks in a 13-10 vote, with several advisors saying they had concerns about use of the drug in pregnant women.</p><p><blockquote>美国食品和药物管理局咨询委员会周二以13比10的投票结果表示，默克公司的实验性抗病毒COVID-19药丸的益处大于其风险，几位顾问表示，他们对孕妇使用该药物感到担忧。</blockquote></p><p> The company is developing the pill, which is called molnupiravir, with privately held Ridgeback Biotherapeutics.</p><p><blockquote>该公司正在与私营公司Ridgeback Biotherapeutics合作开发这种名为molnupiravir的药丸。</blockquote></p><p> The FDA is now expected to deliver its final decision, likely before the end of the year. The regulator often takes into account the recommendation of its advisory committees but is not required to do so.</p><p><blockquote>FDA现在预计将在今年年底前做出最终决定。监管机构通常会考虑其咨询委员会的建议，但不需要这样做。</blockquote></p><p> If molnupiravir is authorized by the FDA in the coming weeks, as expected, the treatment will be the first oral COVID-19 pill that patients can take at home.</p><p><blockquote>如果molnupiravir像预期的那样在未来几周内获得FDA的授权，这种治疗将是患者可以在家服用的第一种口服新冠肺炎药丸。</blockquote></p><p> Members of the Antimicrobial Drugs Advisory Committee also suggested a safety-monitoring program, expressed concerns about prescribing the drug to those who are immunocompromised, and shared their concerns about the overall efficacy of the pill.</p><p><blockquote>抗菌药物咨询委员会的成员还建议了一个安全监测计划，表达了对向免疫功能低下的人开该药物的担忧，并分享了他们对该药物整体疗效的担忧。</blockquote></p><p> \"With the continued spread of the virus and the emergence of variants, additional treatments for COVID-19 are urgently needed. That is why we are moving with speed and rigor to pursue authorizations and to accelerate broad global access to this investigational medicine,\" Dean Li, executive vice president and president of Merck Research Laboratories, said in a statement. \"We are grateful to the members of the advisory committee who reviewed our application, as well as to the patients and investigators who participated in our clinical trials, and we will continue to work with the FDA as the agency completes its review.\"</p><p><blockquote>默克研究实验室执行副总裁兼总裁Dean Li在一份声明中表示：“随着病毒的持续传播和变种的出现，迫切需要针对COVID-19的额外治疗方法。这就是为什么我们正在快速、严格地寻求授权并加速全球广泛获得这种研究药物。”“我们感谢审查我们申请的咨询委员会成员，以及参与我们临床试验的患者和研究人员，随着FDA完成审查，我们将继续与FDA合作。”</blockquote></p><p> Some Wall Street analysts had predicted that the advisers would vote in support of authorization, but with a cautious approach.</p><p><blockquote>一些华尔街分析师曾预测，顾问们将投票支持授权，但态度谨慎。</blockquote></p><p> \"Despite these reservations, molnupiravir is also likely to be approved, and demand is likely to exceed their 20 [million] course supply in 2022,\" SVB Leerink analysts wrote on Friday.</p><p><blockquote>SVB Leerink分析师周五写道：“尽管有这些保留，molnupiravir也有可能获得批准，并且需求可能会在2022年超过2000万个课程供应量。”</blockquote></p><p> Of the COVID-19 treatments that are currently available, most are used to care for very sick, hospitalized people. This includes the steroid dexamethasone and Gilead Sciences Inc.'s Veklury.</p><p><blockquote>在目前可用的新冠肺炎治疗方法中，大多数用于护理重病住院患者。这包括类固醇地塞米松和吉利德科学公司的Veklury。</blockquote></p><p> The monoclonal antibodies developed by Eli Lilly & Co., Regeneron Pharmaceuticals Inc. (REGN), and Vir Biotechnology Inc. and GlaxoSmithKline can be used to treat people with mild or moderate cases of COVID-19, but these treatments have to be administered by an infusion in a clinical setting.</p><p><blockquote>由礼来公司、再生元制药公司开发的单克隆抗体。（REGN）、Vir Biotechnology Inc.和葛兰素史克可用于治疗轻度或中度COVID-19病例的人，但这些治疗必须在临床环境中通过输注进行。</blockquote></p><p> Molnupiravir was once held as a game changer in the course of the pandemic, but its importance has shifted as new data from the clinical trial came out and a competitor stepped up.</p><p><blockquote>Molnupiravir曾被视为大流行期间的游戏规则改变者，但随着临床试验新数据的出现和竞争对手的崛起，其重要性已经发生了变化。</blockquote></p><p> Wall Street's interest in Merck's pill began to wane in November when Pfizer Inc. <a href=\"https://laohu8.com/S/PFE\">$(PFE)$</a> produced even more compelling results for its COVID-19 drug candidate, demonstrating that Paxlovid reduced the risk of hospitalization and death by a stunning 89% in a clinical trial. The company filed for emergency authorization later in the month.</p><p><blockquote>去年11月，当辉瑞公司(Pfizer Inc.)上市时，华尔街对默克公司(Merck)的药物的兴趣开始减弱。<a href=\"https://laohu8.com/S/PFE\">$(PFE)$</a>其COVID-19候选药物产生了更令人信服的结果，表明Paxlovid在临床试验中将住院和死亡风险降低了惊人的89%。该公司于本月晚些时候申请了紧急授权。</blockquote></p><p> Then, last week, Merck shared that its pill reduced the risk of hospitalization and death by 30% in a clinical trial--and not 50% as reported in the interim results. Wall Street is now factoring in growing worries about the omicron variant and the continuing need for new and better treatments for COVID-19.</p><p><blockquote>然后，上周，默克公司表示，其药物在临床试验中将住院和死亡风险降低了30%，而不是中期结果中报告的50%。华尔街现在正在考虑对奥密克戎变种日益增长的担忧，以及对新的更好的COVID-19治疗方法的持续需求。</blockquote></p><p> \"Concerns over the new omicron variant are increasing expectations on the potential of Pfizer's COVID-19 vaccine Comirnaty and updated data from Merck's oral anti-viral molnupiravir are increasing expectations for Pfizer's anti-viral Paxlovid,\" Mizuho Securities analysts told investors on Monday.</p><p><blockquote>瑞穗证券分析师周一对投资者表示：“对新奥密克戎变种的担忧增加了人们对辉瑞COVID-19疫苗Comirnaty潜力的预期，而默克口服抗病毒药物molnupiravir的最新数据也增加了人们对辉瑞抗病毒药物Paxlovid的预期。”</blockquote></p><p> Analysts were once over the moon about the sales potential of the first oral COVID-19 pill that works, predicting between $5 billion and $7 billion in sales next year alone. But the arrival of new efficacy data dragged down interest in both the drug and Merck's stock.</p><p><blockquote>分析师一度对第一种有效的口服COVID-19药丸的销售潜力感到欣喜若狂，预计仅明年的销售额就将达到50亿至70亿美元。但新疗效数据的到来拖累了人们对该药物和默克股票的兴趣。</blockquote></p><p> Citi on Monday downgraded Merck's stock to neutral, from buy, citing concerns about the company's experimental HIV drug islatravir and about molnupiravir.</p><p><blockquote>花旗周一将默克公司的股票评级从买入下调至中性，理由是对该公司实验性艾滋病毒药物islatravir和molnupiravir的担忧。</blockquote></p><p> Merck is seeking authorization for molnupiravir in adults who have tested positive for the virus, are experiencing mild or moderate symptoms, and are at high risk for severe disease. Patients are expected to start treatment within five days of symptoms.</p><p><blockquote>默克公司正在寻求molnupiravir在病毒检测呈阳性、出现轻度或中度症状以及患严重疾病高风险的成年人中的授权。患者预计在出现症状后五天内开始治疗。</blockquote></p><p> The Phase 2/3, randomized, placebo-controlled, double-blind study only enrolled people who were unvaccinated; however, it's unclear whether the pill could be used to treat vaccinated individuals with breakthrough infections if it is authorized.</p><p><blockquote>这项2/3期、随机、安慰剂对照、双盲研究仅招募了未接种疫苗的人；然而，尚不清楚如果获得授权，该药丸是否可用于治疗突破性感染的接种疫苗个体。</blockquote></p><p> Molnupiravir has already been authorized for use in the U.K.</p><p><blockquote>Molnupiravir已被授权在英国使用。</blockquote></p><p></p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Merck shares jumped 5.3% in premarket trading<blockquote>默克股价在盘前交易中上涨5.3%</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; 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}\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nMerck shares jumped 5.3% in premarket trading<blockquote>默克股价在盘前交易中上涨5.3%</blockquote>\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/1079075236\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Tiger Newspress </p>\n<p class=\"h-time smaller\">2021-12-01 17:14</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<p>Merck shares jumped 5.3% in premarket trading as FDA advisers recommended its COVID-19 pill in close vote.</p><p><blockquote>由于FDA顾问以势均力敌的投票推荐其COVID-19药物，默克股价在盘前交易中上涨5.3%。</blockquote></p><p> <img src=\"https://static.tigerbbs.com/52b0f147fff1ac74d32cd5d5643fe2b3\" tg-width=\"850\" tg-height=\"620\" referrerpolicy=\"no-referrer\"></p><p><blockquote></blockquote></p><p> The Food and Drug Administration advisory committee said Tuesday the benefits of Merck & Co.'s experimental antiviral COVID-19 pill outweigh its risks in a 13-10 vote, with several advisors saying they had concerns about use of the drug in pregnant women.</p><p><blockquote>美国食品和药物管理局咨询委员会周二以13比10的投票结果表示，默克公司的实验性抗病毒COVID-19药丸的益处大于其风险，几位顾问表示，他们对孕妇使用该药物感到担忧。</blockquote></p><p> The company is developing the pill, which is called molnupiravir, with privately held Ridgeback Biotherapeutics.</p><p><blockquote>该公司正在与私营公司Ridgeback Biotherapeutics合作开发这种名为molnupiravir的药丸。</blockquote></p><p> The FDA is now expected to deliver its final decision, likely before the end of the year. The regulator often takes into account the recommendation of its advisory committees but is not required to do so.</p><p><blockquote>FDA现在预计将在今年年底前做出最终决定。监管机构通常会考虑其咨询委员会的建议，但不需要这样做。</blockquote></p><p> If molnupiravir is authorized by the FDA in the coming weeks, as expected, the treatment will be the first oral COVID-19 pill that patients can take at home.</p><p><blockquote>如果molnupiravir像预期的那样在未来几周内获得FDA的授权，这种治疗将是患者可以在家服用的第一种口服新冠肺炎药丸。</blockquote></p><p> Members of the Antimicrobial Drugs Advisory Committee also suggested a safety-monitoring program, expressed concerns about prescribing the drug to those who are immunocompromised, and shared their concerns about the overall efficacy of the pill.</p><p><blockquote>抗菌药物咨询委员会的成员还建议了一个安全监测计划，表达了对向免疫功能低下的人开该药物的担忧，并分享了他们对该药物整体疗效的担忧。</blockquote></p><p> \"With the continued spread of the virus and the emergence of variants, additional treatments for COVID-19 are urgently needed. That is why we are moving with speed and rigor to pursue authorizations and to accelerate broad global access to this investigational medicine,\" Dean Li, executive vice president and president of Merck Research Laboratories, said in a statement. \"We are grateful to the members of the advisory committee who reviewed our application, as well as to the patients and investigators who participated in our clinical trials, and we will continue to work with the FDA as the agency completes its review.\"</p><p><blockquote>默克研究实验室执行副总裁兼总裁Dean Li在一份声明中表示：“随着病毒的持续传播和变种的出现，迫切需要针对COVID-19的额外治疗方法。这就是为什么我们正在快速、严格地寻求授权并加速全球广泛获得这种研究药物。”“我们感谢审查我们申请的咨询委员会成员，以及参与我们临床试验的患者和研究人员，随着FDA完成审查，我们将继续与FDA合作。”</blockquote></p><p> Some Wall Street analysts had predicted that the advisers would vote in support of authorization, but with a cautious approach.</p><p><blockquote>一些华尔街分析师曾预测，顾问们将投票支持授权，但态度谨慎。</blockquote></p><p> \"Despite these reservations, molnupiravir is also likely to be approved, and demand is likely to exceed their 20 [million] course supply in 2022,\" SVB Leerink analysts wrote on Friday.</p><p><blockquote>SVB Leerink分析师周五写道：“尽管有这些保留，molnupiravir也有可能获得批准，并且需求可能会在2022年超过2000万个课程供应量。”</blockquote></p><p> Of the COVID-19 treatments that are currently available, most are used to care for very sick, hospitalized people. This includes the steroid dexamethasone and Gilead Sciences Inc.'s Veklury.</p><p><blockquote>在目前可用的新冠肺炎治疗方法中，大多数用于护理重病住院患者。这包括类固醇地塞米松和吉利德科学公司的Veklury。</blockquote></p><p> The monoclonal antibodies developed by Eli Lilly & Co., Regeneron Pharmaceuticals Inc. (REGN), and Vir Biotechnology Inc. and GlaxoSmithKline can be used to treat people with mild or moderate cases of COVID-19, but these treatments have to be administered by an infusion in a clinical setting.</p><p><blockquote>由礼来公司、再生元制药公司开发的单克隆抗体。（REGN）、Vir Biotechnology Inc.和葛兰素史克可用于治疗轻度或中度COVID-19病例的人，但这些治疗必须在临床环境中通过输注进行。</blockquote></p><p> Molnupiravir was once held as a game changer in the course of the pandemic, but its importance has shifted as new data from the clinical trial came out and a competitor stepped up.</p><p><blockquote>Molnupiravir曾被视为大流行期间的游戏规则改变者，但随着临床试验新数据的出现和竞争对手的崛起，其重要性已经发生了变化。</blockquote></p><p> Wall Street's interest in Merck's pill began to wane in November when Pfizer Inc. <a href=\"https://laohu8.com/S/PFE\">$(PFE)$</a> produced even more compelling results for its COVID-19 drug candidate, demonstrating that Paxlovid reduced the risk of hospitalization and death by a stunning 89% in a clinical trial. The company filed for emergency authorization later in the month.</p><p><blockquote>去年11月，当辉瑞公司(Pfizer Inc.)上市时，华尔街对默克公司(Merck)的药物的兴趣开始减弱。<a href=\"https://laohu8.com/S/PFE\">$(PFE)$</a>其COVID-19候选药物产生了更令人信服的结果，表明Paxlovid在临床试验中将住院和死亡风险降低了惊人的89%。该公司于本月晚些时候申请了紧急授权。</blockquote></p><p> Then, last week, Merck shared that its pill reduced the risk of hospitalization and death by 30% in a clinical trial--and not 50% as reported in the interim results. Wall Street is now factoring in growing worries about the omicron variant and the continuing need for new and better treatments for COVID-19.</p><p><blockquote>然后，上周，默克公司表示，其药物在临床试验中将住院和死亡风险降低了30%，而不是中期结果中报告的50%。华尔街现在正在考虑对奥密克戎变种日益增长的担忧，以及对新的更好的COVID-19治疗方法的持续需求。</blockquote></p><p> \"Concerns over the new omicron variant are increasing expectations on the potential of Pfizer's COVID-19 vaccine Comirnaty and updated data from Merck's oral anti-viral molnupiravir are increasing expectations for Pfizer's anti-viral Paxlovid,\" Mizuho Securities analysts told investors on Monday.</p><p><blockquote>瑞穗证券分析师周一对投资者表示：“对新奥密克戎变种的担忧增加了人们对辉瑞COVID-19疫苗Comirnaty潜力的预期，而默克口服抗病毒药物molnupiravir的最新数据也增加了人们对辉瑞抗病毒药物Paxlovid的预期。”</blockquote></p><p> Analysts were once over the moon about the sales potential of the first oral COVID-19 pill that works, predicting between $5 billion and $7 billion in sales next year alone. But the arrival of new efficacy data dragged down interest in both the drug and Merck's stock.</p><p><blockquote>分析师一度对第一种有效的口服COVID-19药丸的销售潜力感到欣喜若狂，预计仅明年的销售额就将达到50亿至70亿美元。但新疗效数据的到来拖累了人们对该药物和默克股票的兴趣。</blockquote></p><p> Citi on Monday downgraded Merck's stock to neutral, from buy, citing concerns about the company's experimental HIV drug islatravir and about molnupiravir.</p><p><blockquote>花旗周一将默克公司的股票评级从买入下调至中性，理由是对该公司实验性艾滋病毒药物islatravir和molnupiravir的担忧。</blockquote></p><p> Merck is seeking authorization for molnupiravir in adults who have tested positive for the virus, are experiencing mild or moderate symptoms, and are at high risk for severe disease. Patients are expected to start treatment within five days of symptoms.</p><p><blockquote>默克公司正在寻求molnupiravir在病毒检测呈阳性、出现轻度或中度症状以及患严重疾病高风险的成年人中的授权。患者预计在出现症状后五天内开始治疗。</blockquote></p><p> The Phase 2/3, randomized, placebo-controlled, double-blind study only enrolled people who were unvaccinated; however, it's unclear whether the pill could be used to treat vaccinated individuals with breakthrough infections if it is authorized.</p><p><blockquote>这项2/3期、随机、安慰剂对照、双盲研究仅招募了未接种疫苗的人；然而，尚不清楚如果获得授权，该药丸是否可用于治疗突破性感染的接种疫苗个体。</blockquote></p><p> Molnupiravir has already been authorized for use in the U.K.</p><p><blockquote>Molnupiravir已被授权在英国使用。</blockquote></p><p></p>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"MRK":"默沙东"},"is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1116877933","content_text":"Merck shares jumped 5.3% in premarket trading as FDA advisers recommended its COVID-19 pill in close vote.\n\nThe Food and Drug Administration advisory committee said Tuesday the benefits of Merck & Co.'s experimental antiviral COVID-19 pill outweigh its risks in a 13-10 vote, with several advisors saying they had concerns about use of the drug in pregnant women.\nThe company is developing the pill, which is called molnupiravir, with privately held Ridgeback Biotherapeutics.\nThe FDA is now expected to deliver its final decision, likely before the end of the year. The regulator often takes into account the recommendation of its advisory committees but is not required to do so.\nIf molnupiravir is authorized by the FDA in the coming weeks, as expected, the treatment will be the first oral COVID-19 pill that patients can take at home.\nMembers of the Antimicrobial Drugs Advisory Committee also suggested a safety-monitoring program, expressed concerns about prescribing the drug to those who are immunocompromised, and shared their concerns about the overall efficacy of the pill.\n\"With the continued spread of the virus and the emergence of variants, additional treatments for COVID-19 are urgently needed. That is why we are moving with speed and rigor to pursue authorizations and to accelerate broad global access to this investigational medicine,\" Dean Li, executive vice president and president of Merck Research Laboratories, said in a statement. \"We are grateful to the members of the advisory committee who reviewed our application, as well as to the patients and investigators who participated in our clinical trials, and we will continue to work with the FDA as the agency completes its review.\"\nSome Wall Street analysts had predicted that the advisers would vote in support of authorization, but with a cautious approach.\n\"Despite these reservations, molnupiravir is also likely to be approved, and demand is likely to exceed their 20 [million] course supply in 2022,\" SVB Leerink analysts wrote on Friday.\nOf the COVID-19 treatments that are currently available, most are used to care for very sick, hospitalized people. This includes the steroid dexamethasone and Gilead Sciences Inc.'s Veklury.\nThe monoclonal antibodies developed by Eli Lilly & Co., Regeneron Pharmaceuticals Inc. (REGN), and Vir Biotechnology Inc. and GlaxoSmithKline can be used to treat people with mild or moderate cases of COVID-19, but these treatments have to be administered by an infusion in a clinical setting.\nMolnupiravir was once held as a game changer in the course of the pandemic, but its importance has shifted as new data from the clinical trial came out and a competitor stepped up.\nWall Street's interest in Merck's pill began to wane in November when Pfizer Inc. $(PFE)$ produced even more compelling results for its COVID-19 drug candidate, demonstrating that Paxlovid reduced the risk of hospitalization and death by a stunning 89% in a clinical trial. The company filed for emergency authorization later in the month.\nThen, last week, Merck shared that its pill reduced the risk of hospitalization and death by 30% in a clinical trial--and not 50% as reported in the interim results. Wall Street is now factoring in growing worries about the omicron variant and the continuing need for new and better treatments for COVID-19.\n\"Concerns over the new omicron variant are increasing expectations on the potential of Pfizer's COVID-19 vaccine Comirnaty and updated data from Merck's oral anti-viral molnupiravir are increasing expectations for Pfizer's anti-viral Paxlovid,\" Mizuho Securities analysts told investors on Monday.\nAnalysts were once over the moon about the sales potential of the first oral COVID-19 pill that works, predicting between $5 billion and $7 billion in sales next year alone. But the arrival of new efficacy data dragged down interest in both the drug and Merck's stock.\nCiti on Monday downgraded Merck's stock to neutral, from buy, citing concerns about the company's experimental HIV drug islatravir and about molnupiravir.\nMerck is seeking authorization for molnupiravir in adults who have tested positive for the virus, are experiencing mild or moderate symptoms, and are at high risk for severe disease. Patients are expected to start treatment within five days of symptoms.\nThe Phase 2/3, randomized, placebo-controlled, double-blind study only enrolled people who were unvaccinated; however, it's unclear whether the pill could be used to treat vaccinated individuals with breakthrough infections if it is authorized.\nMolnupiravir has already been authorized for use in the U.K.","news_type":1,"symbols_score_info":{"MRK":0.9}},"isVote":1,"tweetType":1,"viewCount":1708,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":879574401,"gmtCreate":1636758992535,"gmtModify":1636758992535,"author":{"id":"3582016082149562","authorId":"3582016082149562","name":"Charis4455","avatar":"https://static.tigerbbs.com/170154e3e4358555276582209b5e7550","crmLevel":11,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3582016082149562","idStr":"3582016082149562"},"themes":[],"htmlText":"Cool","listText":"Cool","text":"Cool","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":2,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/879574401","repostId":"1163118124","repostType":4,"isVote":1,"tweetType":1,"viewCount":1743,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0}],"hots":[{"id":603919337,"gmtCreate":1638350710918,"gmtModify":1638350710990,"author":{"id":"3582016082149562","authorId":"3582016082149562","name":"Charis4455","avatar":"https://static.tigerbbs.com/170154e3e4358555276582209b5e7550","crmLevel":11,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3582016082149562","idStr":"3582016082149562"},"themes":[],"htmlText":"Huatz ","listText":"Huatz ","text":"Huatz","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":8,"commentSize":1,"repostSize":0,"link":"https://laohu8.com/post/603919337","repostId":"1116877933","repostType":2,"repost":{"id":"1116877933","kind":"news","weMediaInfo":{"introduction":"Providing stock market headlines, business news, financials and earnings ","home_visible":1,"media_name":"Tiger Newspress","id":"1079075236","head_image":"https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba"},"pubTimestamp":1638350081,"share":"https://www.laohu8.com/m/news/1116877933?lang=zh_CN&edition=full","pubTime":"2021-12-01 17:14","market":"us","language":"en","title":"Merck shares jumped 5.3% in premarket trading<blockquote>默克股价在盘前交易中上涨5.3%</blockquote>","url":"https://stock-news.laohu8.com/highlight/detail?id=1116877933","media":"Tiger Newspress","summary":"Merck shares jumped 5.3% in premarket trading as FDA advisers recommended its COVID-19 pill in close","content":"<p>Merck shares jumped 5.3% in premarket trading as FDA advisers recommended its COVID-19 pill in close vote.</p><p><blockquote>由于FDA顾问以势均力敌的投票推荐其COVID-19药物，默克股价在盘前交易中上涨5.3%。</blockquote></p><p> <img src=\"https://static.tigerbbs.com/52b0f147fff1ac74d32cd5d5643fe2b3\" tg-width=\"850\" tg-height=\"620\" referrerpolicy=\"no-referrer\"></p><p><blockquote></blockquote></p><p> The Food and Drug Administration advisory committee said Tuesday the benefits of Merck & Co.'s experimental antiviral COVID-19 pill outweigh its risks in a 13-10 vote, with several advisors saying they had concerns about use of the drug in pregnant women.</p><p><blockquote>美国食品和药物管理局咨询委员会周二以13比10的投票结果表示，默克公司的实验性抗病毒COVID-19药丸的益处大于其风险，几位顾问表示，他们对孕妇使用该药物感到担忧。</blockquote></p><p> The company is developing the pill, which is called molnupiravir, with privately held Ridgeback Biotherapeutics.</p><p><blockquote>该公司正在与私营公司Ridgeback Biotherapeutics合作开发这种名为molnupiravir的药丸。</blockquote></p><p> The FDA is now expected to deliver its final decision, likely before the end of the year. The regulator often takes into account the recommendation of its advisory committees but is not required to do so.</p><p><blockquote>FDA现在预计将在今年年底前做出最终决定。监管机构通常会考虑其咨询委员会的建议，但不需要这样做。</blockquote></p><p> If molnupiravir is authorized by the FDA in the coming weeks, as expected, the treatment will be the first oral COVID-19 pill that patients can take at home.</p><p><blockquote>如果molnupiravir像预期的那样在未来几周内获得FDA的授权，这种治疗将是患者可以在家服用的第一种口服新冠肺炎药丸。</blockquote></p><p> Members of the Antimicrobial Drugs Advisory Committee also suggested a safety-monitoring program, expressed concerns about prescribing the drug to those who are immunocompromised, and shared their concerns about the overall efficacy of the pill.</p><p><blockquote>抗菌药物咨询委员会的成员还建议了一个安全监测计划，表达了对向免疫功能低下的人开该药物的担忧，并分享了他们对该药物整体疗效的担忧。</blockquote></p><p> \"With the continued spread of the virus and the emergence of variants, additional treatments for COVID-19 are urgently needed. That is why we are moving with speed and rigor to pursue authorizations and to accelerate broad global access to this investigational medicine,\" Dean Li, executive vice president and president of Merck Research Laboratories, said in a statement. \"We are grateful to the members of the advisory committee who reviewed our application, as well as to the patients and investigators who participated in our clinical trials, and we will continue to work with the FDA as the agency completes its review.\"</p><p><blockquote>默克研究实验室执行副总裁兼总裁Dean Li在一份声明中表示：“随着病毒的持续传播和变种的出现，迫切需要针对COVID-19的额外治疗方法。这就是为什么我们正在快速、严格地寻求授权并加速全球广泛获得这种研究药物。”“我们感谢审查我们申请的咨询委员会成员，以及参与我们临床试验的患者和研究人员，随着FDA完成审查，我们将继续与FDA合作。”</blockquote></p><p> Some Wall Street analysts had predicted that the advisers would vote in support of authorization, but with a cautious approach.</p><p><blockquote>一些华尔街分析师曾预测，顾问们将投票支持授权，但态度谨慎。</blockquote></p><p> \"Despite these reservations, molnupiravir is also likely to be approved, and demand is likely to exceed their 20 [million] course supply in 2022,\" SVB Leerink analysts wrote on Friday.</p><p><blockquote>SVB Leerink分析师周五写道：“尽管有这些保留，molnupiravir也有可能获得批准，并且需求可能会在2022年超过2000万个课程供应量。”</blockquote></p><p> Of the COVID-19 treatments that are currently available, most are used to care for very sick, hospitalized people. This includes the steroid dexamethasone and Gilead Sciences Inc.'s Veklury.</p><p><blockquote>在目前可用的新冠肺炎治疗方法中，大多数用于护理重病住院患者。这包括类固醇地塞米松和吉利德科学公司的Veklury。</blockquote></p><p> The monoclonal antibodies developed by Eli Lilly & Co., Regeneron Pharmaceuticals Inc. (REGN), and Vir Biotechnology Inc. and GlaxoSmithKline can be used to treat people with mild or moderate cases of COVID-19, but these treatments have to be administered by an infusion in a clinical setting.</p><p><blockquote>由礼来公司、再生元制药公司开发的单克隆抗体。（REGN）、Vir Biotechnology Inc.和葛兰素史克可用于治疗轻度或中度COVID-19病例的人，但这些治疗必须在临床环境中通过输注进行。</blockquote></p><p> Molnupiravir was once held as a game changer in the course of the pandemic, but its importance has shifted as new data from the clinical trial came out and a competitor stepped up.</p><p><blockquote>Molnupiravir曾被视为大流行期间的游戏规则改变者，但随着临床试验新数据的出现和竞争对手的崛起，其重要性已经发生了变化。</blockquote></p><p> Wall Street's interest in Merck's pill began to wane in November when Pfizer Inc. <a href=\"https://laohu8.com/S/PFE\">$(PFE)$</a> produced even more compelling results for its COVID-19 drug candidate, demonstrating that Paxlovid reduced the risk of hospitalization and death by a stunning 89% in a clinical trial. The company filed for emergency authorization later in the month.</p><p><blockquote>去年11月，当辉瑞公司(Pfizer Inc.)上市时，华尔街对默克公司(Merck)的药物的兴趣开始减弱。<a href=\"https://laohu8.com/S/PFE\">$(PFE)$</a>其COVID-19候选药物产生了更令人信服的结果，表明Paxlovid在临床试验中将住院和死亡风险降低了惊人的89%。该公司于本月晚些时候申请了紧急授权。</blockquote></p><p> Then, last week, Merck shared that its pill reduced the risk of hospitalization and death by 30% in a clinical trial--and not 50% as reported in the interim results. Wall Street is now factoring in growing worries about the omicron variant and the continuing need for new and better treatments for COVID-19.</p><p><blockquote>然后，上周，默克公司表示，其药物在临床试验中将住院和死亡风险降低了30%，而不是中期结果中报告的50%。华尔街现在正在考虑对奥密克戎变种日益增长的担忧，以及对新的更好的COVID-19治疗方法的持续需求。</blockquote></p><p> \"Concerns over the new omicron variant are increasing expectations on the potential of Pfizer's COVID-19 vaccine Comirnaty and updated data from Merck's oral anti-viral molnupiravir are increasing expectations for Pfizer's anti-viral Paxlovid,\" Mizuho Securities analysts told investors on Monday.</p><p><blockquote>瑞穗证券分析师周一对投资者表示：“对新奥密克戎变种的担忧增加了人们对辉瑞COVID-19疫苗Comirnaty潜力的预期，而默克口服抗病毒药物molnupiravir的最新数据也增加了人们对辉瑞抗病毒药物Paxlovid的预期。”</blockquote></p><p> Analysts were once over the moon about the sales potential of the first oral COVID-19 pill that works, predicting between $5 billion and $7 billion in sales next year alone. But the arrival of new efficacy data dragged down interest in both the drug and Merck's stock.</p><p><blockquote>分析师一度对第一种有效的口服COVID-19药丸的销售潜力感到欣喜若狂，预计仅明年的销售额就将达到50亿至70亿美元。但新疗效数据的到来拖累了人们对该药物和默克股票的兴趣。</blockquote></p><p> Citi on Monday downgraded Merck's stock to neutral, from buy, citing concerns about the company's experimental HIV drug islatravir and about molnupiravir.</p><p><blockquote>花旗周一将默克公司的股票评级从买入下调至中性，理由是对该公司实验性艾滋病毒药物islatravir和molnupiravir的担忧。</blockquote></p><p> Merck is seeking authorization for molnupiravir in adults who have tested positive for the virus, are experiencing mild or moderate symptoms, and are at high risk for severe disease. Patients are expected to start treatment within five days of symptoms.</p><p><blockquote>默克公司正在寻求molnupiravir在病毒检测呈阳性、出现轻度或中度症状以及患严重疾病高风险的成年人中的授权。患者预计在出现症状后五天内开始治疗。</blockquote></p><p> The Phase 2/3, randomized, placebo-controlled, double-blind study only enrolled people who were unvaccinated; however, it's unclear whether the pill could be used to treat vaccinated individuals with breakthrough infections if it is authorized.</p><p><blockquote>这项2/3期、随机、安慰剂对照、双盲研究仅招募了未接种疫苗的人；然而，尚不清楚如果获得授权，该药丸是否可用于治疗突破性感染的接种疫苗个体。</blockquote></p><p> Molnupiravir has already been authorized for use in the U.K.</p><p><blockquote>Molnupiravir已被授权在英国使用。</blockquote></p><p></p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Merck shares jumped 5.3% in premarket trading<blockquote>默克股价在盘前交易中上涨5.3%</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; 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}\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nMerck shares jumped 5.3% in premarket trading<blockquote>默克股价在盘前交易中上涨5.3%</blockquote>\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/1079075236\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Tiger Newspress </p>\n<p class=\"h-time smaller\">2021-12-01 17:14</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<p>Merck shares jumped 5.3% in premarket trading as FDA advisers recommended its COVID-19 pill in close vote.</p><p><blockquote>由于FDA顾问以势均力敌的投票推荐其COVID-19药物，默克股价在盘前交易中上涨5.3%。</blockquote></p><p> <img src=\"https://static.tigerbbs.com/52b0f147fff1ac74d32cd5d5643fe2b3\" tg-width=\"850\" tg-height=\"620\" referrerpolicy=\"no-referrer\"></p><p><blockquote></blockquote></p><p> The Food and Drug Administration advisory committee said Tuesday the benefits of Merck & Co.'s experimental antiviral COVID-19 pill outweigh its risks in a 13-10 vote, with several advisors saying they had concerns about use of the drug in pregnant women.</p><p><blockquote>美国食品和药物管理局咨询委员会周二以13比10的投票结果表示，默克公司的实验性抗病毒COVID-19药丸的益处大于其风险，几位顾问表示，他们对孕妇使用该药物感到担忧。</blockquote></p><p> The company is developing the pill, which is called molnupiravir, with privately held Ridgeback Biotherapeutics.</p><p><blockquote>该公司正在与私营公司Ridgeback Biotherapeutics合作开发这种名为molnupiravir的药丸。</blockquote></p><p> The FDA is now expected to deliver its final decision, likely before the end of the year. The regulator often takes into account the recommendation of its advisory committees but is not required to do so.</p><p><blockquote>FDA现在预计将在今年年底前做出最终决定。监管机构通常会考虑其咨询委员会的建议，但不需要这样做。</blockquote></p><p> If molnupiravir is authorized by the FDA in the coming weeks, as expected, the treatment will be the first oral COVID-19 pill that patients can take at home.</p><p><blockquote>如果molnupiravir像预期的那样在未来几周内获得FDA的授权，这种治疗将是患者可以在家服用的第一种口服新冠肺炎药丸。</blockquote></p><p> Members of the Antimicrobial Drugs Advisory Committee also suggested a safety-monitoring program, expressed concerns about prescribing the drug to those who are immunocompromised, and shared their concerns about the overall efficacy of the pill.</p><p><blockquote>抗菌药物咨询委员会的成员还建议了一个安全监测计划，表达了对向免疫功能低下的人开该药物的担忧，并分享了他们对该药物整体疗效的担忧。</blockquote></p><p> \"With the continued spread of the virus and the emergence of variants, additional treatments for COVID-19 are urgently needed. That is why we are moving with speed and rigor to pursue authorizations and to accelerate broad global access to this investigational medicine,\" Dean Li, executive vice president and president of Merck Research Laboratories, said in a statement. \"We are grateful to the members of the advisory committee who reviewed our application, as well as to the patients and investigators who participated in our clinical trials, and we will continue to work with the FDA as the agency completes its review.\"</p><p><blockquote>默克研究实验室执行副总裁兼总裁Dean Li在一份声明中表示：“随着病毒的持续传播和变种的出现，迫切需要针对COVID-19的额外治疗方法。这就是为什么我们正在快速、严格地寻求授权并加速全球广泛获得这种研究药物。”“我们感谢审查我们申请的咨询委员会成员，以及参与我们临床试验的患者和研究人员，随着FDA完成审查，我们将继续与FDA合作。”</blockquote></p><p> Some Wall Street analysts had predicted that the advisers would vote in support of authorization, but with a cautious approach.</p><p><blockquote>一些华尔街分析师曾预测，顾问们将投票支持授权，但态度谨慎。</blockquote></p><p> \"Despite these reservations, molnupiravir is also likely to be approved, and demand is likely to exceed their 20 [million] course supply in 2022,\" SVB Leerink analysts wrote on Friday.</p><p><blockquote>SVB Leerink分析师周五写道：“尽管有这些保留，molnupiravir也有可能获得批准，并且需求可能会在2022年超过2000万个课程供应量。”</blockquote></p><p> Of the COVID-19 treatments that are currently available, most are used to care for very sick, hospitalized people. This includes the steroid dexamethasone and Gilead Sciences Inc.'s Veklury.</p><p><blockquote>在目前可用的新冠肺炎治疗方法中，大多数用于护理重病住院患者。这包括类固醇地塞米松和吉利德科学公司的Veklury。</blockquote></p><p> The monoclonal antibodies developed by Eli Lilly & Co., Regeneron Pharmaceuticals Inc. (REGN), and Vir Biotechnology Inc. and GlaxoSmithKline can be used to treat people with mild or moderate cases of COVID-19, but these treatments have to be administered by an infusion in a clinical setting.</p><p><blockquote>由礼来公司、再生元制药公司开发的单克隆抗体。（REGN）、Vir Biotechnology Inc.和葛兰素史克可用于治疗轻度或中度COVID-19病例的人，但这些治疗必须在临床环境中通过输注进行。</blockquote></p><p> Molnupiravir was once held as a game changer in the course of the pandemic, but its importance has shifted as new data from the clinical trial came out and a competitor stepped up.</p><p><blockquote>Molnupiravir曾被视为大流行期间的游戏规则改变者，但随着临床试验新数据的出现和竞争对手的崛起，其重要性已经发生了变化。</blockquote></p><p> Wall Street's interest in Merck's pill began to wane in November when Pfizer Inc. <a href=\"https://laohu8.com/S/PFE\">$(PFE)$</a> produced even more compelling results for its COVID-19 drug candidate, demonstrating that Paxlovid reduced the risk of hospitalization and death by a stunning 89% in a clinical trial. The company filed for emergency authorization later in the month.</p><p><blockquote>去年11月，当辉瑞公司(Pfizer Inc.)上市时，华尔街对默克公司(Merck)的药物的兴趣开始减弱。<a href=\"https://laohu8.com/S/PFE\">$(PFE)$</a>其COVID-19候选药物产生了更令人信服的结果，表明Paxlovid在临床试验中将住院和死亡风险降低了惊人的89%。该公司于本月晚些时候申请了紧急授权。</blockquote></p><p> Then, last week, Merck shared that its pill reduced the risk of hospitalization and death by 30% in a clinical trial--and not 50% as reported in the interim results. Wall Street is now factoring in growing worries about the omicron variant and the continuing need for new and better treatments for COVID-19.</p><p><blockquote>然后，上周，默克公司表示，其药物在临床试验中将住院和死亡风险降低了30%，而不是中期结果中报告的50%。华尔街现在正在考虑对奥密克戎变种日益增长的担忧，以及对新的更好的COVID-19治疗方法的持续需求。</blockquote></p><p> \"Concerns over the new omicron variant are increasing expectations on the potential of Pfizer's COVID-19 vaccine Comirnaty and updated data from Merck's oral anti-viral molnupiravir are increasing expectations for Pfizer's anti-viral Paxlovid,\" Mizuho Securities analysts told investors on Monday.</p><p><blockquote>瑞穗证券分析师周一对投资者表示：“对新奥密克戎变种的担忧增加了人们对辉瑞COVID-19疫苗Comirnaty潜力的预期，而默克口服抗病毒药物molnupiravir的最新数据也增加了人们对辉瑞抗病毒药物Paxlovid的预期。”</blockquote></p><p> Analysts were once over the moon about the sales potential of the first oral COVID-19 pill that works, predicting between $5 billion and $7 billion in sales next year alone. But the arrival of new efficacy data dragged down interest in both the drug and Merck's stock.</p><p><blockquote>分析师一度对第一种有效的口服COVID-19药丸的销售潜力感到欣喜若狂，预计仅明年的销售额就将达到50亿至70亿美元。但新疗效数据的到来拖累了人们对该药物和默克股票的兴趣。</blockquote></p><p> Citi on Monday downgraded Merck's stock to neutral, from buy, citing concerns about the company's experimental HIV drug islatravir and about molnupiravir.</p><p><blockquote>花旗周一将默克公司的股票评级从买入下调至中性，理由是对该公司实验性艾滋病毒药物islatravir和molnupiravir的担忧。</blockquote></p><p> Merck is seeking authorization for molnupiravir in adults who have tested positive for the virus, are experiencing mild or moderate symptoms, and are at high risk for severe disease. Patients are expected to start treatment within five days of symptoms.</p><p><blockquote>默克公司正在寻求molnupiravir在病毒检测呈阳性、出现轻度或中度症状以及患严重疾病高风险的成年人中的授权。患者预计在出现症状后五天内开始治疗。</blockquote></p><p> The Phase 2/3, randomized, placebo-controlled, double-blind study only enrolled people who were unvaccinated; however, it's unclear whether the pill could be used to treat vaccinated individuals with breakthrough infections if it is authorized.</p><p><blockquote>这项2/3期、随机、安慰剂对照、双盲研究仅招募了未接种疫苗的人；然而，尚不清楚如果获得授权，该药丸是否可用于治疗突破性感染的接种疫苗个体。</blockquote></p><p> Molnupiravir has already been authorized for use in the U.K.</p><p><blockquote>Molnupiravir已被授权在英国使用。</blockquote></p><p></p>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"MRK":"默沙东"},"is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1116877933","content_text":"Merck shares jumped 5.3% in premarket trading as FDA advisers recommended its COVID-19 pill in close vote.\n\nThe Food and Drug Administration advisory committee said Tuesday the benefits of Merck & Co.'s experimental antiviral COVID-19 pill outweigh its risks in a 13-10 vote, with several advisors saying they had concerns about use of the drug in pregnant women.\nThe company is developing the pill, which is called molnupiravir, with privately held Ridgeback Biotherapeutics.\nThe FDA is now expected to deliver its final decision, likely before the end of the year. The regulator often takes into account the recommendation of its advisory committees but is not required to do so.\nIf molnupiravir is authorized by the FDA in the coming weeks, as expected, the treatment will be the first oral COVID-19 pill that patients can take at home.\nMembers of the Antimicrobial Drugs Advisory Committee also suggested a safety-monitoring program, expressed concerns about prescribing the drug to those who are immunocompromised, and shared their concerns about the overall efficacy of the pill.\n\"With the continued spread of the virus and the emergence of variants, additional treatments for COVID-19 are urgently needed. That is why we are moving with speed and rigor to pursue authorizations and to accelerate broad global access to this investigational medicine,\" Dean Li, executive vice president and president of Merck Research Laboratories, said in a statement. \"We are grateful to the members of the advisory committee who reviewed our application, as well as to the patients and investigators who participated in our clinical trials, and we will continue to work with the FDA as the agency completes its review.\"\nSome Wall Street analysts had predicted that the advisers would vote in support of authorization, but with a cautious approach.\n\"Despite these reservations, molnupiravir is also likely to be approved, and demand is likely to exceed their 20 [million] course supply in 2022,\" SVB Leerink analysts wrote on Friday.\nOf the COVID-19 treatments that are currently available, most are used to care for very sick, hospitalized people. This includes the steroid dexamethasone and Gilead Sciences Inc.'s Veklury.\nThe monoclonal antibodies developed by Eli Lilly & Co., Regeneron Pharmaceuticals Inc. (REGN), and Vir Biotechnology Inc. and GlaxoSmithKline can be used to treat people with mild or moderate cases of COVID-19, but these treatments have to be administered by an infusion in a clinical setting.\nMolnupiravir was once held as a game changer in the course of the pandemic, but its importance has shifted as new data from the clinical trial came out and a competitor stepped up.\nWall Street's interest in Merck's pill began to wane in November when Pfizer Inc. $(PFE)$ produced even more compelling results for its COVID-19 drug candidate, demonstrating that Paxlovid reduced the risk of hospitalization and death by a stunning 89% in a clinical trial. The company filed for emergency authorization later in the month.\nThen, last week, Merck shared that its pill reduced the risk of hospitalization and death by 30% in a clinical trial--and not 50% as reported in the interim results. Wall Street is now factoring in growing worries about the omicron variant and the continuing need for new and better treatments for COVID-19.\n\"Concerns over the new omicron variant are increasing expectations on the potential of Pfizer's COVID-19 vaccine Comirnaty and updated data from Merck's oral anti-viral molnupiravir are increasing expectations for Pfizer's anti-viral Paxlovid,\" Mizuho Securities analysts told investors on Monday.\nAnalysts were once over the moon about the sales potential of the first oral COVID-19 pill that works, predicting between $5 billion and $7 billion in sales next year alone. But the arrival of new efficacy data dragged down interest in both the drug and Merck's stock.\nCiti on Monday downgraded Merck's stock to neutral, from buy, citing concerns about the company's experimental HIV drug islatravir and about molnupiravir.\nMerck is seeking authorization for molnupiravir in adults who have tested positive for the virus, are experiencing mild or moderate symptoms, and are at high risk for severe disease. Patients are expected to start treatment within five days of symptoms.\nThe Phase 2/3, randomized, placebo-controlled, double-blind study only enrolled people who were unvaccinated; however, it's unclear whether the pill could be used to treat vaccinated individuals with breakthrough infections if it is authorized.\nMolnupiravir has already been authorized for use in the U.K.","news_type":1,"symbols_score_info":{"MRK":0.9}},"isVote":1,"tweetType":1,"viewCount":1708,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":879574401,"gmtCreate":1636758992535,"gmtModify":1636758992535,"author":{"id":"3582016082149562","authorId":"3582016082149562","name":"Charis4455","avatar":"https://static.tigerbbs.com/170154e3e4358555276582209b5e7550","crmLevel":11,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3582016082149562","idStr":"3582016082149562"},"themes":[],"htmlText":"Cool","listText":"Cool","text":"Cool","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":2,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/879574401","repostId":"1163118124","repostType":4,"isVote":1,"tweetType":1,"viewCount":1743,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":607649897,"gmtCreate":1639536362062,"gmtModify":1639536362062,"author":{"id":"3582016082149562","authorId":"3582016082149562","name":"Charis4455","avatar":"https://static.tigerbbs.com/170154e3e4358555276582209b5e7550","crmLevel":11,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3582016082149562","idStr":"3582016082149562"},"themes":[],"htmlText":":(","listText":":(","text":":(","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/607649897","repostId":"1180160205","repostType":4,"isVote":1,"tweetType":1,"viewCount":2042,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0}],"lives":[]}
