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2021-03-22

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Analysts cheer ‘surprisingly positive’ AstraZeneca U.S. trial data

KEY POINTS Monday’s trial results showed the vaccine had an overall efficacy of 79% in preventing s

Analysts cheer ‘surprisingly positive’ AstraZeneca U.S. trial data

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overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nAnalysts cheer ‘surprisingly positive’ AstraZeneca U.S. trial data\n</h2>\n\n<h4 class=\"meta\">\n\n\n2021-03-22 21:43 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://www.cnbc.com/2021/03/22/analysts-cheer-surprisingly-positive-astrazeneca-us-trial-data.html><strong>cnbc</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>KEY POINTS\n\nMonday’s trial results showed the vaccine had an overall efficacy of 79% in preventing symptomatic Covid-19 and was 100% effective in preventing severe disease and hospitalization.\n...</p>\n\n<a href=\"https://www.cnbc.com/2021/03/22/analysts-cheer-surprisingly-positive-astrazeneca-us-trial-data.html\">Web Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{},"source_url":"https://www.cnbc.com/2021/03/22/analysts-cheer-surprisingly-positive-astrazeneca-us-trial-data.html","is_english":true,"share_image_url":"https://static.laohu8.com/72bb72e1b84c09fca865c6dcb1bbcd16","article_id":"1196983012","content_text":"KEY POINTS\n\nMonday’s trial results showed the vaccine had an overall efficacy of 79% in preventing symptomatic Covid-19 and was 100% effective in preventing severe disease and hospitalization.\nJefferies healthcare analyst Peter Welford called the data “surprisingly positive” in a research note.\n“Data like this reported today that more conclusively demonstrates the efficacy and safety of AZD1222 is certainly something to celebrate,” Adam Barker, healthcare analyst at Shore Capital, said.\n\nAstraZeneca announced its hotly anticipated late-stage U.S. trial results this morning and healthcare analysts welcomed the news, saying it provides further validation of the vaccine.\nThe trial included over 30,000 participants and showed that the vaccine had an overall efficacy of 79% in preventing symptomatic Covid-19 and was 100% effective in preventing severe disease and hospitalization.\nEfficacy was consistent across age and ethnic group, with 80% efficacy in participants aged 65 years and over. The vaccine, known as AZD1222 and developed with the University of Oxford, was well-tolerated and the independent data safety monitoring board identified no safety concerns related to the vaccine.\nData exceeded expectations\nJefferies healthcare analyst Peter Welford called the data “surprisingly positive” in a research note published Monday, writing that the interim analysis was better than expected.\nMeanwhile Adam Barker, healthcare analyst at Shore Capital, highlighted that: “This is arguably the first trial for AZD1222 which has shown compelling efficacy in those 65 years and older”.\nThis is important because there were some questions about efficacy in this age group as previous studies were hampered by a smaller number of elderly participants. In this trial, 20% of the participants were 65 years or older and 60% had co-morbidities which put them at increased risk of developing severe disease.\nCritically, Monday’s trial data confirmed the safety profile of the vaccine. Barker highlighted that given this data is from a single trial which uses a single dosing regimen, it removes the complications of data interpretation that has been seen in the past with the AstraZeneca-Oxford jab.\nBarker added that the lack of evidence for blood clots in the study was also reassuring given recent concerns. “However, we are not surprised by this data given the evidence for a link between the vaccine and blood clots was already fairly weak.”\nAstraZeneca said it will continue to analyze the data and prepare for the primary analysis to be submitted to the U.S. Food and Drug Administration for emergency use authorization in the coming weeks. The vaccine has already been granted a conditional marketing authorization or emergency use in more than 70 countries across six continents.\nDosing regimen a key question for the FDA\n“I can’t see why the regulator wouldn’t approve it,” Barker wrote, but cautioned that the detailed data was still outstanding.\nOne key question for the FDA will be what dosing regimen they will endorse should they ultimately approve the vaccine.\n“This trial is based on dosing 4 weeks apart, but we know efficacy may be greater if you dose with a longer interval(up to 12 weeks) and countries like the U.K. have successfully used this ‘longer duration between doses’ strategy to vaccinate more people quickly,” he flagged.\nSo the question for the FDA is whether they recommend giving the two doses four weeks apart — given that’s what was tested in the U.S. trial — or include data from the U.K. and elsewhere which suggests a longer duration is appropriate.\nWelford also noted the sub-optimal dosing regimen used in this trial. “The trial evaluated the 4-week dosing schedule, but we have evidence to suggest the vaccine works better with a longer dosing interval,” he said.\n“Primary analysis of the Phase III clinical trials from the U.K., Brazil and South Africa showed 62% efficacy when given the vaccine was given at an interval of 4 to 12 weeks but efficacy increased to 82% when the interval was stretched to 12 weeks.”\nBeyond dosing, analysts are also watching for additional detail on how the vaccine protects against different variants. This is expected to be included in the package of data submitted to the FDA.\nWhen it comes to comparing today’s efficacy data to that from some of the other vaccine-makers, Welford cautioned that since the initial vaccine readouts from Pfizer and Moderna, Covid-19 variants have become increasingly common so the efficacy data is not directly comparable across the different vaccines.\nBarker added that the trial results gave the vaccine important validation. “Given its cost and ease of storage and distribution, AZD1222 was once described as a ‘vaccine for the world’. This is a fair label in our opinion,” he wrote. “Data like this reported today that more conclusively demonstrates the efficacy and safety of AZD1222 is certainly something to celebrate.”\nAstraZeneca has pledged to distribute the vaccine at no profit for the duration of the pandemic. The company’s shares traded 2% higher in London on Monday.","news_type":1,"symbols_score_info":{"AZN":0.9,"AZN.UK":0.9}},"isVote":1,"tweetType":1,"viewCount":383,"commentLimit":10,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"symbols":[],"verified":2,"subType":0,"readableState":1,"langContent":"EN","currentLanguage":"EN","warmUpFlag":false,"orderFlag":false,"shareable":true,"causeOfNotShareable":"","featuresForAnalytics":[],"commentAndTweetFlag":false,"andRepostAutoSelectedFlag":false,"upFlag":false,"length":4,"xxTargetLangEnum":"ORIG"},"commentList":[],"hasMoreComment":false,"orderType":2}