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Covid-19 Antibody Drugs Are Challenged by Omicron, Preliminary Testing Indicates<blockquote>新冠抗体药物受奥密克戎挑战初步检测显示</blockquote>

Regeneron said its antibody drug cocktail was found to lose effectiveness against the new variant A

Covid-19 Antibody Drugs Are Challenged by Omicron, Preliminary Testing Indicates<blockquote>新冠抗体药物受奥密克戎挑战初步检测显示</blockquote>

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{"i18n":{"language":"zh_CN"},"data":{"magic":2,"id":609544749,"tweetId":"609544749","gmtCreate":1638314157014,"gmtModify":1638314157014,"author":{"id":4093776015978190,"idStr":"4093776015978190","authorId":4093776015978190,"authorIdStr":"4093776015978190","name":"UNknown","avatar":"https://static.tigerbbs.com/544ab1c11c2e3063efc979d573c9bf0f","vip":1,"userType":1,"introduction":"","boolIsFan":false,"boolIsHead":false,"crmLevel":12,"crmLevelSwitch":0,"individualDisplayBadges":[],"fanSize":9,"starInvestorFlag":false},"themes":[],"images":[],"coverImages":[],"extraTitle":"","html":"<html><head></head><body>Ok&nbsp;Thanks&nbsp;</body></html>","htmlText":"<html><head></head><body>Ok&nbsp;Thanks&nbsp;</body></html>","text":"Ok Thanks","highlighted":1,"essential":1,"paper":1,"likeSize":1,"commentSize":0,"repostSize":0,"favoriteSize":0,"link":"https://laohu8.com/post/609544749","repostId":1192203085,"repostType":4,"repost":{"id":"1192203085","kind":"news","pubTimestamp":1638273550,"share":"https://www.laohu8.com/m/news/1192203085?lang=zh_CN&edition=full","pubTime":"2021-11-30 19:59","market":"us","language":"en","title":"Covid-19 Antibody Drugs Are Challenged by Omicron, Preliminary Testing Indicates<blockquote>新冠抗体药物受奥密克戎挑战初步检测显示</blockquote>","url":"https://stock-news.laohu8.com/highlight/detail?id=1192203085","media":"The Wall Street Journal","summary":"Regeneron said its antibody drug cocktail was found to lose effectiveness against the new variant\nA ","content":"Regeneron said its antibody drug cocktail was found to lose effectiveness against the new variant<blockquote>再生元表示，其抗体药物鸡尾酒被发现对新变种失去效力</blockquote> <img src=\"https://static.tigerbbs.com/ed6086131617e6933fe07f3e46cd5c26\" tg-width=\"1290\" tg-height=\"859\" referrerpolicy=\"no-referrer\">A monoclonal antibody treatment site in Pembroke Pines, Fla., earlier this year.<blockquote>今年早些时候，佛罗里达州彭布罗克派恩斯的一个单克隆抗体治疗点。</blockquote> Preliminary tests indicate the Covid-19 antibody drug cocktail from Regeneron Pharmaceuticals Inc. loses effectiveness against Omicron, the company said Tuesday, a sign that some products in an important class of therapies might need modifying if the new strain becomes widespread.<blockquote>再生元制药公司周二表示，初步测试表明，该公司的Covid-19抗体药物鸡尾酒对奥密克戎病毒失去了效力，这表明，如果新毒株广泛传播，一类重要疗法中的一些产品可能需要修改。</blockquote> Separate testing of another authorized Covid-19 antibody drug cocktail, from&nbsp;Eli Lilly&amp; Co., indicates it also isn’t as effective against Omicron, outside scientists said. Lilly said it is testing the new variant against its antibody treatment and wouldn’t speculate on what the results will be.<blockquote>外部科学家表示，对礼来公司(Eli Lilly&amp;Co.)的另一种授权的Covid-19抗体药物混合物进行的单独测试表明，它对奥密克戎病也没有那么有效。礼来公司表示，正在针对其抗体治疗测试新变种，但不愿猜测结果会是什么。</blockquote> The findings are the early results of researchers’ race to assess the impact of the&nbsp;new Omicron variant&nbsp;on Covid-19 treatments that patients, doctors and hospitals have been relying on, as well as pills in development that have promised to keep people out of the hospital.<blockquote>这些发现是研究人员竞相评估新的奥密克戎病毒变种对患者、医生和医院一直依赖的Covid-19治疗的影响的早期结果，以及正在开发的有望让人们远离医院的药物。</blockquote> Researchers say some antibody therapies are likely to be especially vulnerable to Omicron because it contains mutations to the spike protein that the Regeneron and Lilly drugs target, while other drugs should hold up well because they attack elements of the virus unchanged in the variant.<blockquote>研究人员表示，一些抗体疗法可能特别容易受到奥密克戎病毒的影响，因为它含有再生元和礼来药物所针对的刺突蛋白的突变，而其他药物应该表现良好，因为它们攻击的是变种中未改变的病毒元素。</blockquote> Monoclonal antibodies are lab-made molecules derived from survivors of Covid-19 or mice engineered to have human immune systems. When given soon after infection, the drugs attach to the surface of the coronavirus and prevent it from replicating itself in new cells.<blockquote>单克隆抗体是实验室制造的分子，来自新冠肺炎幸存者或被改造成具有人类免疫系统的小鼠。当感染后不久给药时，这些药物会附着在冠状病毒的表面，阻止它在新细胞中自我复制。</blockquote> They are the only drugs authorized to treat patients, before they require hospitalization, who are at high risk of developing severe cases.<blockquote>它们是唯一被授权在需要住院治疗患者之前治疗这些患者的药物，这些患者具有发展为严重病例的高风险。</blockquote> The drugs differ from vaccines, which train the immune system how to defend against the virus, including with the production of antibodies. Last year, former&nbsp;President Donald Trump credited Regeneron’s drug&nbsp;with his speedy recovery from Covid-19.<blockquote>这些药物不同于疫苗，疫苗训练免疫系统如何防御病毒，包括产生抗体。去年，前总统唐纳德·特朗普将他从Covid-19中迅速康复归功于再生元的药物。</blockquote> Regeneron said it would be able to quantify the impact of the variant in coming weeks, after further testing is done.<blockquote>再生元表示，在进行进一步测试后，它将能够在未来几周内量化该变体的影响。</blockquote> <img src=\"https://static.tigerbbs.com/6e7fac5c4630025e6c5ad28d2c3efbfa\" tg-width=\"1050\" tg-height=\"700\" referrerpolicy=\"no-referrer\">Antiviral pills such as Pfizer’s Paxlovid appear to be unaffected by the variant.<blockquote>辉瑞公司的Paxlovid等抗病毒药物似乎不受该变种的影响。</blockquote> If final testing shows that its antibody drugs are less effective against Omicron, Regeneron has developed alternative antibodies that it can push into clinical testing and that it thinks will retain effectiveness against the variant, said George Yancopoulos, the company’s president and chief scientific officer.<blockquote>该公司总裁兼首席科学官George Yancopoulos表示，如果最终测试表明其抗体药物对奥密克戎病毒的效果较差，再生元已经开发出替代抗体，可以将其推向临床测试，并且认为这些抗体将保留对该变种的有效性。</blockquote> One of Regeneron’s alternative antibodies is already in clinical testing, which the company began in anticipation of new variants emerging over time.<blockquote>再生元的一种替代抗体已经处于临床测试阶段，该公司预计随着时间的推移会出现新的变种。</blockquote> The Omicron variant was identified last week by scientists in South Africa, prompting drug researchers to scramble to see if the relatively small medicine chest of Covid-19 treatments would still work against the new strain if it ends up spreading widely.<blockquote>南非科学家上周发现了奥密克戎病毒变种，促使药物研究人员争先恐后地看看，如果新冠肺炎病毒最终广泛传播，相对较小的新冠肺炎治疗药箱是否仍能对抗新毒株。</blockquote> “What we have to admit is, in the course of the past six days, our urgency has increased,” Dr. Yancopoulos said in an interview. “What started out as a backup plan has now been made a lot more urgent.”<blockquote>“我们必须承认的是，在过去的六天里，我们的紧迫性有所增加，”扬科普洛斯博士在接受采访时说。“最初的备用计划现在变得更加紧迫。”</blockquote> Scientists at the Fred Hutchinson Cancer Research Center in Seattle found that individual mutations from Omicron reduced or eliminated the ability of Regeneron’s and Lilly’s drugs to attach to the virus, said Allie Greaney, a Ph.D. candidate at the center and the University of Washington in Seattle.<blockquote>西雅图Fred Hutchinson癌症研究中心的科学家发现，奥密克戎病毒的个体突变降低或消除了再生元和礼来公司的药物附着在病毒上的能力。该中心和西雅图华盛顿大学的候选人。</blockquote> More comprehensive tests of the drugs against the entire variant are needed to fully understand the impact, she said. “I’m not certain what the exact magnitude of effect would be, but probably less effective,” said Ms. Greaney.<blockquote>她说，需要对针对整个变种的药物进行更全面的测试，以充分了解其影响。“我不确定效果的确切程度，但效果可能会较差，”格雷尼女士说。</blockquote> Lilly is in the process of testing the new variant against its drug, a combination of&nbsp;two antibodies called bamlanivimab and etesevimab,said Nicole Kallewaard, a Lilly virologist and research adviser.<blockquote>礼来公司病毒学家兼研究顾问Nicole Kallewaard表示，礼来公司正在针对其药物测试新变种，该药物是两种抗体的组合，称为bamlanivimab和etesevimab。</blockquote> She declined to comment on the results showing reduced effectiveness against individual Omicron mutations, because the results may differ when all of the mutations are combined.<blockquote>她拒绝对显示针对单个奥密克戎突变的有效性降低的结果发表评论，因为当所有突变结合在一起时，结果可能会有所不同。</blockquote> “I think that we need to wait for confirmation of the whole virus,” said Dr. Kallewaard. “Hopefully, the data will come in the next few weeks.”<blockquote>“我认为我们需要等待整个病毒的确认，”Kallewaard博士说。“希望数据能在未来几周内公布。”</blockquote> A rise in the prevalence of Omicron could present an opportunity for competitors who say their drugs don’t appear in preliminary testing to be affected by the variant, including&nbsp;Vir Biotechnology&nbsp;Inc.&nbsp;and GlaxoSmithKline PLC, whose drug&nbsp;sotrovimab was authorized for emergency use&nbsp;earlier this year.<blockquote>奥密克戎病毒患病率的上升可能会给那些表示其药物在初步测试中没有出现的竞争对手带来受到该变种影响的机会，其中包括Vir Biotechnology Inc.和葛兰素史克PLC，其药物sotrovimab早些时候被授权紧急使用今年。</blockquote> Fred Hutchinson researchers also said their initial testing indicated the Vir-GSK antibody drug retained its effectiveness.<blockquote>Fred Hutchinson研究人员还表示，他们的初步测试表明Vir-GSK抗体药物保留了其有效性。</blockquote> Adagio Therapeutics&nbsp;Inc.,a biotech with a Covid-19 antibody drug in clinical trials, said its antibody also appears to be unaffected by the new variant.<blockquote>Adagio Therapeutics Inc.是一家正在进行临床试验的新冠肺炎抗体药物的生物技术公司，该公司表示，其抗体似乎也不受新变种的影响。</blockquote> Vir, Glaxo and Adagio said they are conducting further tests to confirm that their drugs aren’t affected by Omicron.<blockquote>Vir、葛兰素史克和Adagio表示，他们正在进行进一步测试，以确认他们的药物不受奥密克戎病的影响。</blockquote> Omicron poses a threat to lab-made antibody drugs as well as antibodies generated by vaccines, because the new variant has mutations on the spike protein part of the virus where antibodies are known to frequently attach themselves, scientists say.<blockquote>科学家说，奥密克戎病毒对实验室制造的抗体药物以及疫苗产生的抗体构成威胁，因为这种新变种在病毒的刺突蛋白部分发生了突变，已知抗体经常附着在该部分。</blockquote> Vir and Adagio officials said the companies designed their antibodies with the aim of targeting spots on the virus that are common across different coronaviruses that remained stable even after numerous mutations over many years.<blockquote>Vir和Adagio官员表示，两家公司设计抗体的目的是针对病毒上不同冠状病毒中常见的点，这些点即使在多年多次突变后仍保持稳定。</blockquote> “They bind to a region of the virus that through decades of evolution has not changed a lot,” Adagio Chief Executive Tillman Gerngross said in an interview. “Those conserved areas make the virus much more vulnerable” to antibodies.<blockquote>Adagio首席执行官蒂尔曼·格恩格罗斯(Tillman Gerngross)在接受采访时表示：“它们与病毒的一个区域结合，该区域经过数十年的进化并没有发生太大变化。”“这些保守区域使病毒更容易受到抗体的攻击”。</blockquote> It will take at least two weeks to create a version of the full Omicron virus variant and test antibody drugs against it, company officials said. Still, scientists say they are concerned by what they know already about the variant’s ability to evade antibodies produced by vaccines, prior infection or from drug treatment.<blockquote>公司官员表示，至少需要两周时间才能创建完整的奥密克戎病毒变种版本并测试针对其的抗体药物。尽管如此，科学家们表示，他们对这种变异逃避疫苗、先前感染或药物治疗产生的抗体的能力感到担忧。</blockquote> “Omicron hasn’t become the next Delta,” Vir Chief Scientific Officer Skip Virgin said in an interview. But “we think the extent of the mutations, the number of them, means that the world needs to take Omicron very seriously.”<blockquote>“奥密克戎还没有成为下一个三角洲，”Vir首席科学官Skip Virgin在接受采访时表示。但“我们认为突变的程度和数量意味着世界需要非常认真地对待奥密克戎。”</blockquote> Antiviral drugs, including pills from&nbsp;Merck&amp; Co. and partner Ridgeback Biotherapeutics LP and from&nbsp;Pfizer&nbsp;Inc.&nbsp;that are being&nbsp;evaluated for authorization,appear to be unaffected by the variant because they target a different site on the virus, said Michel Nussenzweig, an immunologist at Rockefeller University.<blockquote>洛克菲勒大学免疫学家米歇尔·努森茨威格(Michel Nussenzweig)表示，抗病毒药物，包括默克公司(Merck&amp;Co.)和合作伙伴Ridgeback Biotherapeutics LP以及辉瑞公司(Pfizer Inc.)正在接受授权评估的药物，似乎不受该变种的影响，因为它们针对病毒上的不同位点。</blockquote> Doctors and patients have been looking forward to authorization of the pills, which in clinical trials have&nbsp;reduced the risk of hospitalization&nbsp;if taken early enough.<blockquote>医生和患者一直在期待这种药物的批准，在临床试验中，如果尽早服用，这种药物可以降低住院风险。</blockquote> “The targets of the pills appear to be under less pressure and may be OK, but this too needs to be tested,” said Dr. Nussenzweig.<blockquote>“药物的目标似乎压力较小，可能没问题，但这也需要测试，”努森茨威格博士说。</blockquote> Pfizer and Merck said they expect their drugs to be effective against Omicron.<blockquote>辉瑞和默克表示，他们预计他们的药物将有效对抗奥密克戎病。</blockquote> Gilead SciencesInc.&nbsp;also said it expects&nbsp;Veklury, its antiviral drug&nbsp;used to treat hospitalized patients, to retain effectiveness against Omicron as it has against other variants of concern.<blockquote>吉利德科学公司还表示，预计其用于治疗住院患者的抗病毒药物Veklury将保持对奥密克戎病毒的有效性，就像它对其他令人担忧的变种一样。</blockquote>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; 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Co., indicates it also isn’t as effective against Omicron, outside scientists said. Lilly said it is testing the new variant against its antibody treatment and wouldn’t speculate on what the results will be.<blockquote>外部科学家表示，对礼来公司(Eli Lilly&amp;Co.)的另一种授权的Covid-19抗体药物混合物进行的单独测试表明，它对奥密克戎病也没有那么有效。礼来公司表示，正在针对其抗体治疗测试新变种，但不愿猜测结果会是什么。</blockquote> The findings are the early results of researchers’ race to assess the impact of the&nbsp;new Omicron variant&nbsp;on Covid-19 treatments that patients, doctors and hospitals have been relying on, as well as pills in development that have promised to keep people out of the hospital.<blockquote>这些发现是研究人员竞相评估新的奥密克戎病毒变种对患者、医生和医院一直依赖的Covid-19治疗的影响的早期结果，以及正在开发的有望让人们远离医院的药物。</blockquote> Researchers say some antibody therapies are likely to be especially vulnerable to Omicron because it contains mutations to the spike protein that the Regeneron and Lilly drugs target, while other drugs should hold up well because they attack elements of the virus unchanged in the variant.<blockquote>研究人员表示，一些抗体疗法可能特别容易受到奥密克戎病毒的影响，因为它含有再生元和礼来药物所针对的刺突蛋白的突变，而其他药物应该表现良好，因为它们攻击的是变种中未改变的病毒元素。</blockquote> Monoclonal antibodies are lab-made molecules derived from survivors of Covid-19 or mice engineered to have human immune systems. When given soon after infection, the drugs attach to the surface of the coronavirus and prevent it from replicating itself in new cells.<blockquote>单克隆抗体是实验室制造的分子，来自新冠肺炎幸存者或被改造成具有人类免疫系统的小鼠。当感染后不久给药时，这些药物会附着在冠状病毒的表面，阻止它在新细胞中自我复制。</blockquote> They are the only drugs authorized to treat patients, before they require hospitalization, who are at high risk of developing severe cases.<blockquote>它们是唯一被授权在需要住院治疗患者之前治疗这些患者的药物，这些患者具有发展为严重病例的高风险。</blockquote> The drugs differ from vaccines, which train the immune system how to defend against the virus, including with the production of antibodies. Last year, former&nbsp;President Donald Trump credited Regeneron’s drug&nbsp;with his speedy recovery from Covid-19.<blockquote>这些药物不同于疫苗，疫苗训练免疫系统如何防御病毒，包括产生抗体。去年，前总统唐纳德·特朗普将他从Covid-19中迅速康复归功于再生元的药物。</blockquote> Regeneron said it would be able to quantify the impact of the variant in coming weeks, after further testing is done.<blockquote>再生元表示，在进行进一步测试后，它将能够在未来几周内量化该变体的影响。</blockquote> <img src=\"https://static.tigerbbs.com/6e7fac5c4630025e6c5ad28d2c3efbfa\" tg-width=\"1050\" tg-height=\"700\" referrerpolicy=\"no-referrer\">Antiviral pills such as Pfizer’s Paxlovid appear to be unaffected by the variant.<blockquote>辉瑞公司的Paxlovid等抗病毒药物似乎不受该变种的影响。</blockquote> If final testing shows that its antibody drugs are less effective against Omicron, Regeneron has developed alternative antibodies that it can push into clinical testing and that it thinks will retain effectiveness against the variant, said George Yancopoulos, the company’s president and chief scientific officer.<blockquote>该公司总裁兼首席科学官George Yancopoulos表示，如果最终测试表明其抗体药物对奥密克戎病毒的效果较差，再生元已经开发出替代抗体，可以将其推向临床测试，并且认为这些抗体将保留对该变种的有效性。</blockquote> One of Regeneron’s alternative antibodies is already in clinical testing, which the company began in anticipation of new variants emerging over time.<blockquote>再生元的一种替代抗体已经处于临床测试阶段，该公司预计随着时间的推移会出现新的变种。</blockquote> The Omicron variant was identified last week by scientists in South Africa, prompting drug researchers to scramble to see if the relatively small medicine chest of Covid-19 treatments would still work against the new strain if it ends up spreading widely.<blockquote>南非科学家上周发现了奥密克戎病毒变种，促使药物研究人员争先恐后地看看，如果新冠肺炎病毒最终广泛传播，相对较小的新冠肺炎治疗药箱是否仍能对抗新毒株。</blockquote> “What we have to admit is, in the course of the past six days, our urgency has increased,” Dr. Yancopoulos said in an interview. “What started out as a backup plan has now been made a lot more urgent.”<blockquote>“我们必须承认的是，在过去的六天里，我们的紧迫性有所增加，”扬科普洛斯博士在接受采访时说。“最初的备用计划现在变得更加紧迫。”</blockquote> Scientists at the Fred Hutchinson Cancer Research Center in Seattle found that individual mutations from Omicron reduced or eliminated the ability of Regeneron’s and Lilly’s drugs to attach to the virus, said Allie Greaney, a Ph.D. candidate at the center and the University of Washington in Seattle.<blockquote>西雅图Fred Hutchinson癌症研究中心的科学家发现，奥密克戎病毒的个体突变降低或消除了再生元和礼来公司的药物附着在病毒上的能力。该中心和西雅图华盛顿大学的候选人。</blockquote> More comprehensive tests of the drugs against the entire variant are needed to fully understand the impact, she said. “I’m not certain what the exact magnitude of effect would be, but probably less effective,” said Ms. Greaney.<blockquote>她说，需要对针对整个变种的药物进行更全面的测试，以充分了解其影响。“我不确定效果的确切程度，但效果可能会较差，”格雷尼女士说。</blockquote> Lilly is in the process of testing the new variant against its drug, a combination of&nbsp;two antibodies called bamlanivimab and etesevimab,said Nicole Kallewaard, a Lilly virologist and research adviser.<blockquote>礼来公司病毒学家兼研究顾问Nicole Kallewaard表示，礼来公司正在针对其药物测试新变种，该药物是两种抗体的组合，称为bamlanivimab和etesevimab。</blockquote> She declined to comment on the results showing reduced effectiveness against individual Omicron mutations, because the results may differ when all of the mutations are combined.<blockquote>她拒绝对显示针对单个奥密克戎突变的有效性降低的结果发表评论，因为当所有突变结合在一起时，结果可能会有所不同。</blockquote> “I think that we need to wait for confirmation of the whole virus,” said Dr. Kallewaard. “Hopefully, the data will come in the next few weeks.”<blockquote>“我认为我们需要等待整个病毒的确认，”Kallewaard博士说。“希望数据能在未来几周内公布。”</blockquote> A rise in the prevalence of Omicron could present an opportunity for competitors who say their drugs don’t appear in preliminary testing to be affected by the variant, including&nbsp;Vir Biotechnology&nbsp;Inc.&nbsp;and GlaxoSmithKline PLC, whose drug&nbsp;sotrovimab was authorized for emergency use&nbsp;earlier this year.<blockquote>奥密克戎病毒患病率的上升可能会给那些表示其药物在初步测试中没有出现的竞争对手带来受到该变种影响的机会，其中包括Vir Biotechnology Inc.和葛兰素史克PLC，其药物sotrovimab早些时候被授权紧急使用今年。</blockquote> Fred Hutchinson researchers also said their initial testing indicated the Vir-GSK antibody drug retained its effectiveness.<blockquote>Fred Hutchinson研究人员还表示，他们的初步测试表明Vir-GSK抗体药物保留了其有效性。</blockquote> Adagio Therapeutics&nbsp;Inc.,a biotech with a Covid-19 antibody drug in clinical trials, said its antibody also appears to be unaffected by the new variant.<blockquote>Adagio Therapeutics Inc.是一家正在进行临床试验的新冠肺炎抗体药物的生物技术公司，该公司表示，其抗体似乎也不受新变种的影响。</blockquote> Vir, Glaxo and Adagio said they are conducting further tests to confirm that their drugs aren’t affected by Omicron.<blockquote>Vir、葛兰素史克和Adagio表示，他们正在进行进一步测试，以确认他们的药物不受奥密克戎病的影响。</blockquote> Omicron poses a threat to lab-made antibody drugs as well as antibodies generated by vaccines, because the new variant has mutations on the spike protein part of the virus where antibodies are known to frequently attach themselves, scientists say.<blockquote>科学家说，奥密克戎病毒对实验室制造的抗体药物以及疫苗产生的抗体构成威胁，因为这种新变种在病毒的刺突蛋白部分发生了突变，已知抗体经常附着在该部分。</blockquote> Vir and Adagio officials said the companies designed their antibodies with the aim of targeting spots on the virus that are common across different coronaviruses that remained stable even after numerous mutations over many years.<blockquote>Vir和Adagio官员表示，两家公司设计抗体的目的是针对病毒上不同冠状病毒中常见的点，这些点即使在多年多次突变后仍保持稳定。</blockquote> “They bind to a region of the virus that through decades of evolution has not changed a lot,” Adagio Chief Executive Tillman Gerngross said in an interview. “Those conserved areas make the virus much more vulnerable” to antibodies.<blockquote>Adagio首席执行官蒂尔曼·格恩格罗斯(Tillman Gerngross)在接受采访时表示：“它们与病毒的一个区域结合，该区域经过数十年的进化并没有发生太大变化。”“这些保守区域使病毒更容易受到抗体的攻击”。</blockquote> It will take at least two weeks to create a version of the full Omicron virus variant and test antibody drugs against it, company officials said. Still, scientists say they are concerned by what they know already about the variant’s ability to evade antibodies produced by vaccines, prior infection or from drug treatment.<blockquote>公司官员表示，至少需要两周时间才能创建完整的奥密克戎病毒变种版本并测试针对其的抗体药物。尽管如此，科学家们表示，他们对这种变异逃避疫苗、先前感染或药物治疗产生的抗体的能力感到担忧。</blockquote> “Omicron hasn’t become the next Delta,” Vir Chief Scientific Officer Skip Virgin said in an interview. But “we think the extent of the mutations, the number of them, means that the world needs to take Omicron very seriously.”<blockquote>“奥密克戎还没有成为下一个三角洲，”Vir首席科学官Skip Virgin在接受采访时表示。但“我们认为突变的程度和数量意味着世界需要非常认真地对待奥密克戎。”</blockquote> Antiviral drugs, including pills from&nbsp;Merck&amp; Co. and partner Ridgeback Biotherapeutics LP and from&nbsp;Pfizer&nbsp;Inc.&nbsp;that are being&nbsp;evaluated for authorization,appear to be unaffected by the variant because they target a different site on the virus, said Michel Nussenzweig, an immunologist at Rockefeller University.<blockquote>洛克菲勒大学免疫学家米歇尔·努森茨威格(Michel Nussenzweig)表示，抗病毒药物，包括默克公司(Merck&amp;Co.)和合作伙伴Ridgeback Biotherapeutics LP以及辉瑞公司(Pfizer Inc.)正在接受授权评估的药物，似乎不受该变种的影响，因为它们针对病毒上的不同位点。</blockquote> Doctors and patients have been looking forward to authorization of the pills, which in clinical trials have&nbsp;reduced the risk of hospitalization&nbsp;if taken early enough.<blockquote>医生和患者一直在期待这种药物的批准，在临床试验中，如果尽早服用，这种药物可以降低住院风险。</blockquote> “The targets of the pills appear to be under less pressure and may be OK, but this too needs to be tested,” said Dr. Nussenzweig.<blockquote>“药物的目标似乎压力较小，可能没问题，但这也需要测试，”努森茨威格博士说。</blockquote> Pfizer and Merck said they expect their drugs to be effective against Omicron.<blockquote>辉瑞和默克表示，他们预计他们的药物将有效对抗奥密克戎病。</blockquote> Gilead SciencesInc.&nbsp;also said it expects&nbsp;Veklury, its antiviral drug&nbsp;used to treat hospitalized patients, to retain effectiveness against Omicron as it has against other variants of concern.<blockquote>吉利德科学公司还表示，预计其用于治疗住院患者的抗病毒药物Veklury将保持对奥密克戎病毒的有效性，就像它对其他令人担忧的变种一样。</blockquote>\n<div class=\"bt-text\">\n\n\n 来源：<a href=\"https://www.wsj.com/articles/covid-19-antibody-drugs-are-challenged-by-omicron-preliminary-testing-indicates-11638270003?mod=Searchresults_pos1&page=1\">The Wall Street Journal</a>\n为提升您的阅读体验，我们对本页面进行了排版优化\n\n\n</div>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"LLY":"礼来","REGN":"再生元制药公司"},"source_url":"https://www.wsj.com/articles/covid-19-antibody-drugs-are-challenged-by-omicron-preliminary-testing-indicates-11638270003?mod=Searchresults_pos1&page=1","is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1192203085","content_text":"Regeneron said its antibody drug cocktail was found to lose effectiveness against the new variant\nA monoclonal antibody treatment site in Pembroke Pines, Fla., earlier this year.\nPreliminary tests indicate the Covid-19 antibody drug cocktail from Regeneron Pharmaceuticals Inc. loses effectiveness against Omicron, the company said Tuesday, a sign that some products in an important class of therapies might need modifying if the new strain becomes widespread.\nSeparate testing of another authorized Covid-19 antibody drug cocktail, from Eli Lilly& Co., indicates it also isn’t as effective against Omicron, outside scientists said. Lilly said it is testing the new variant against its antibody treatment and wouldn’t speculate on what the results will be.\nThe findings are the early results of researchers’ race to assess the impact of the new Omicron variant on Covid-19 treatments that patients, doctors and hospitals have been relying on, as well as pills in development that have promised to keep people out of the hospital.\nResearchers say some antibody therapies are likely to be especially vulnerable to Omicron because it contains mutations to the spike protein that the Regeneron and Lilly drugs target, while other drugs should hold up well because they attack elements of the virus unchanged in the variant.\nMonoclonal antibodies are lab-made molecules derived from survivors of Covid-19 or mice engineered to have human immune systems. When given soon after infection, the drugs attach to the surface of the coronavirus and prevent it from replicating itself in new cells.\nThey are the only drugs authorized to treat patients, before they require hospitalization, who are at high risk of developing severe cases.\nThe drugs differ from vaccines, which train the immune system how to defend against the virus, including with the production of antibodies. Last year, former President Donald Trump credited Regeneron’s drug with his speedy recovery from Covid-19.\nRegeneron said it would be able to quantify the impact of the variant in coming weeks, after further testing is done.\nAntiviral pills such as Pfizer’s Paxlovid appear to be unaffected by the variant.\nIf final testing shows that its antibody drugs are less effective against Omicron, Regeneron has developed alternative antibodies that it can push into clinical testing and that it thinks will retain effectiveness against the variant, said George Yancopoulos, the company’s president and chief scientific officer.\nOne of Regeneron’s alternative antibodies is already in clinical testing, which the company began in anticipation of new variants emerging over time.\nThe Omicron variant was identified last week by scientists in South Africa, prompting drug researchers to scramble to see if the relatively small medicine chest of Covid-19 treatments would still work against the new strain if it ends up spreading widely.\n“What we have to admit is, in the course of the past six days, our urgency has increased,” Dr. Yancopoulos said in an interview. “What started out as a backup plan has now been made a lot more urgent.”\nScientists at the Fred Hutchinson Cancer Research Center in Seattle found that individual mutations from Omicron reduced or eliminated the ability of Regeneron’s and Lilly’s drugs to attach to the virus, said Allie Greaney, a Ph.D. candidate at the center and the University of Washington in Seattle.\nMore comprehensive tests of the drugs against the entire variant are needed to fully understand the impact, she said. “I’m not certain what the exact magnitude of effect would be, but probably less effective,” said Ms. Greaney.\nLilly is in the process of testing the new variant against its drug, a combination of two antibodies called bamlanivimab and etesevimab,said Nicole Kallewaard, a Lilly virologist and research adviser.\nShe declined to comment on the results showing reduced effectiveness against individual Omicron mutations, because the results may differ when all of the mutations are combined.\n“I think that we need to wait for confirmation of the whole virus,” said Dr. Kallewaard. “Hopefully, the data will come in the next few weeks.”\nA rise in the prevalence of Omicron could present an opportunity for competitors who say their drugs don’t appear in preliminary testing to be affected by the variant, including Vir Biotechnology Inc. and GlaxoSmithKline PLC, whose drug sotrovimab was authorized for emergency use earlier this year.\nFred Hutchinson researchers also said their initial testing indicated the Vir-GSK antibody drug retained its effectiveness.\nAdagio Therapeutics Inc.,a biotech with a Covid-19 antibody drug in clinical trials, said its antibody also appears to be unaffected by the new variant.\nVir, Glaxo and Adagio said they are conducting further tests to confirm that their drugs aren’t affected by Omicron.\nOmicron poses a threat to lab-made antibody drugs as well as antibodies generated by vaccines, because the new variant has mutations on the spike protein part of the virus where antibodies are known to frequently attach themselves, scientists say.\nVir and Adagio officials said the companies designed their antibodies with the aim of targeting spots on the virus that are common across different coronaviruses that remained stable even after numerous mutations over many years.\n“They bind to a region of the virus that through decades of evolution has not changed a lot,” Adagio Chief Executive Tillman Gerngross said in an interview. “Those conserved areas make the virus much more vulnerable” to antibodies.\nIt will take at least two weeks to create a version of the full Omicron virus variant and test antibody drugs against it, company officials said. Still, scientists say they are concerned by what they know already about the variant’s ability to evade antibodies produced by vaccines, prior infection or from drug treatment.\n“Omicron hasn’t become the next Delta,” Vir Chief Scientific Officer Skip Virgin said in an interview. But “we think the extent of the mutations, the number of them, means that the world needs to take Omicron very seriously.”\nAntiviral drugs, including pills from Merck& Co. and partner Ridgeback Biotherapeutics LP and from Pfizer Inc. that are being evaluated for authorization,appear to be unaffected by the variant because they target a different site on the virus, said Michel Nussenzweig, an immunologist at Rockefeller University.\nDoctors and patients have been looking forward to authorization of the pills, which in clinical trials have reduced the risk of hospitalization if taken early enough.\n“The targets of the pills appear to be under less pressure and may be OK, but this too needs to be tested,” said Dr. Nussenzweig.\nPfizer and Merck said they expect their drugs to be effective against Omicron.\nGilead SciencesInc. also said it expects Veklury, its antiviral drug used to treat hospitalized patients, to retain effectiveness against Omicron as it has against other variants of concern.","news_type":1,"symbols_score_info":{"LLY":0.9,"REGN":0.9}},"isVote":1,"tweetType":1,"viewCount":2545,"commentLimit":10,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"symbols":[],"verified":2,"subType":0,"readableState":1,"langContent":"CN","currentLanguage":"CN","warmUpFlag":false,"orderFlag":false,"shareable":true,"causeOfNotShareable":"","featuresForAnalytics":[],"commentAndTweetFlag":false,"andRepostAutoSelectedFlag":false,"upFlag":false,"length":8,"xxTargetLangEnum":"ZH_CN"},"commentList":[],"hasMoreComment":false,"orderType":2}