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三袋地主
三袋地主
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04-23
2025年4月22日
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2025年4月22日
三袋地主
三袋地主
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04-19
2024年4月17日礼来开盘大幅上涨
礼来首个小分子口服GLP-1药物3期临床研究成功 有望颠覆减重药物格局
本报讯(记者李春莲见习记者梁傲男)4月17日,全球制药巨头礼来公司公布了3期临床研究ACHIEVE-1的积极顶线结果,该研究评估了Orforglipron与安慰剂相比,在患有2型糖尿病和仅通过饮食和运动控制不足的成人中的安全性和有效性。4月17日,礼来股价收涨超14%,创下自2023年8月份以来的最大单日涨幅。
礼来首个小分子口服GLP-1药物3期临床研究成功 有望颠覆减重药物格局
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三袋地主
三袋地主
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2024-12-05
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三袋地主
三袋地主
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三袋地主
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2024-11-24
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三袋地主
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2024-04-09
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2023-11-09
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三袋地主
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2022-05-03
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14:07","market":"us","language":"zh","title":"礼来首个小分子口服GLP-1药物3期临床研究成功 有望颠覆减重药物格局","url":"https://stock-news.laohu8.com/highlight/detail?id=2528080431","media":"证券日报","summary":"本报讯(记者李春莲见习记者梁傲男)4月17日,全球制药巨头礼来公司公布了3期临床研究ACHIEVE-1的积极顶线结果,该研究评估了Orforglipron与安慰剂相比,在患有2型糖尿病和仅通过饮食和运动控制不足的成人中的安全性和有效性。4月17日,礼来股价收涨超14%,创下自2023年8月份以来的最大单日涨幅。","content":"<html><body><div>\n<p><img border=\"0\" height=\"276\" src=\"https://webquoteklinepic.eastmoney.com/GetPic.aspx?nid=106.LLY&imageType=k&token=28dfeb41d35cc81d84b4664d7c23c49f&at=1\" width=\"578\"/></p><p> 本报讯 (记者李春莲见习记者梁傲男)4月17日,全球制药巨头<span><a href=\"https://laohu8.com/S/LLY\">礼来</a></span><span></span>公司公布了3期临床研究ACHIEVE-1的积极顶线结果,该研究评估了Orforglipron与安慰剂相比,在患有2型糖尿病和仅通过饮食和运动控制不足的成人中的安全性和有效性。</p><p> 4月17日,<span href=\"http://quote.eastmoney.com/unify/r/106.LLY\" target=\"_blank\" web=\"1\">礼来</span>股价收涨超14%,创下自2023年8月份以来的最大单日涨幅。</p><p> 在业内人士看来,GLP-1<span>减肥药</span><span></span>领域正在从注射剂型向便捷的口服形式转变,而<span href=\"http://quote.eastmoney.com/unify/r/106.LLY\" target=\"_blank\" web=\"1\">礼来</span>已经取得了早期领先优势,有望颠覆减重药物格局。</p><p> 据礼来介绍,Orforglipron是首款无需饮食、饮水控制的口服小分子GLP-1受体激动剂。礼来方面表示,如果该药物未来获批,公司对其实现全球充足的供应充满信心。这将进一步实现礼来长期以来的使命——降低包括2型糖尿病在内的慢性病的影响。</p><p> “目前共有7项评估Orforglipron在糖尿病和肥胖人群中安全性和有效性的3期临床试验,ACHIEVE-1则是其中的首个研究。作为最新的肠促胰岛素类药物,我们很高兴看到它达到了我们对其安全性、耐受性、血糖控制和减重的各项预期,今年年底前我们将获得有关这一研究的更多数据。”礼来制药董事长兼首席执行官戴文睿表示。</p><p> 研究显示,在ACHIEVE项目的第一项3期临床试验中,Orforglipron达到了主要终点,即在40周时,经Orforglipron治疗后糖化血红蛋白(A1C)的降幅显著优于安慰剂组,A1C自8.0%的基线平均降低1.3%至1.6%(使用有效性估计目标)。在关键次要终点,超过65%的患者接受最高剂量的Orforglipron后A1C值降至≤6.5%,低于美国糖尿病协会定义的糖尿病阈值。在另一个关键次要终点,接受Orforglipron的患者在最高剂量下平均减重7.3kg。鉴于患者在研究结束时尚未达到体重平台期,可能表明尚未实现完全减重。</p><p> 礼来方面预计,将在今年年底前向全球监管机构提交Orforglipron用于体重管理的上市申请,预计于2026年提交其用于治疗2型糖尿病的上市申请。</p><p>(文章来源:<span>证券</span><span></span>日报)</p> </div></body></html>","source":"stock_eastmoney","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta 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href=http://finance.eastmoney.com/a/202504183381169424.html><strong>证券日报</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>本报讯 (记者李春莲见习记者梁傲男)4月17日,全球制药巨头礼来公司公布了3期临床研究ACHIEVE-1的积极顶线结果,该研究评估了Orforglipron与安慰剂相比,在患有2型糖尿病和仅通过饮食和运动控制不足的成人中的安全性和有效性。 4月17日,礼来股价收涨超14%,创下自2023年8月份以来的最大单日涨幅。 在业内人士看来,GLP-1减肥药领域正在从注射剂型向便捷的口服形式转变,而礼来...</p>\n\n<a href=\"http://finance.eastmoney.com/a/202504183381169424.html\">Web Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"SG9999017495.SGD":"UGDP UNITED GLOBAL QUALITY GROWTH \"B\" (SGD) ACC","LU1232071149.USD":"AZ FUND 1 GLOBAL GROWTH SELECTOR \"AAZ\" (USDHDG) ACC","LU1093756168.USD":"FRANKLIN K2 ALTERNATIVE STRATEGIES \"A\" (USD) ACC","LU0882574055.USD":"富达全球健康医疗A ACC","LU1720051108.HKD":"ALLIANZ GLOBAL ARTIFICIAL INTELLIGENCE \"AT\" (HKD) ACC","SG9999013999.USD":"UOB UNITED GLOBAL HEALTHCARE FUND (USDHDG) INC","LU0114720955.EUR":"SUSTAINABLE GLOBAL HEALTH CARE \"A\" INC","GLP":"Global Partners 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在业内人士看来,GLP-1减肥药领域正在从注射剂型向便捷的口服形式转变,而礼来已经取得了早期领先优势,有望颠覆减重药物格局。 据礼来介绍,Orforglipron是首款无需饮食、饮水控制的口服小分子GLP-1受体激动剂。礼来方面表示,如果该药物未来获批,公司对其实现全球充足的供应充满信心。这将进一步实现礼来长期以来的使命——降低包括2型糖尿病在内的慢性病的影响。 “目前共有7项评估Orforglipron在糖尿病和肥胖人群中安全性和有效性的3期临床试验,ACHIEVE-1则是其中的首个研究。作为最新的肠促胰岛素类药物,我们很高兴看到它达到了我们对其安全性、耐受性、血糖控制和减重的各项预期,今年年底前我们将获得有关这一研究的更多数据。”礼来制药董事长兼首席执行官戴文睿表示。 研究显示,在ACHIEVE项目的第一项3期临床试验中,Orforglipron达到了主要终点,即在40周时,经Orforglipron治疗后糖化血红蛋白(A1C)的降幅显著优于安慰剂组,A1C自8.0%的基线平均降低1.3%至1.6%(使用有效性估计目标)。在关键次要终点,超过65%的患者接受最高剂量的Orforglipron后A1C值降至≤6.5%,低于美国糖尿病协会定义的糖尿病阈值。在另一个关键次要终点,接受Orforglipron的患者在最高剂量下平均减重7.3kg。鉴于患者在研究结束时尚未达到体重平台期,可能表明尚未实现完全减重。 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