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lawgbk
lawgbk
·
2021-05-11
Comment pls
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lawgbk
lawgbk
·
2021-12-30
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5 Stocks To Watch For December 30, 2021<blockquote>2021 年 12 月 30 日值得关注的 5 只股票</blockquote>
Four Corners Property Trust, Inc. reported acquisition of three Mr. Tire Properties for $2.5 million
5 Stocks To Watch For December 30, 2021<blockquote>2021 年 12 月 30 日值得关注的 5 只股票</blockquote>
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lawgbk
lawgbk
·
2021-12-29
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Pop Culture Group Stock Jumped 22% in Premarket Trading<blockquote>流行文化集团股价在盘前交易中上涨 22%</blockquote>
Pop Culture Group stock jumped 22% in premarket trading.The stock soared nearly 36% yesterday.
Pop Culture Group Stock Jumped 22% in Premarket Trading<blockquote>流行文化集团股价在盘前交易中上涨 22%</blockquote>
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lawgbk
lawgbk
·
2021-12-28
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Toplines Before US Market Open on Tuesday<blockquote>周二美国市场开盘前的顶线</blockquote>
The S&P 500 and Dow futures hit all-time highs on Tuesday, building on a record-setting rally amid t
Toplines Before US Market Open on Tuesday<blockquote>周二美国市场开盘前的顶线</blockquote>
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lawgbk
lawgbk
·
2021-12-26
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lawgbk
lawgbk
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2021-12-25
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lawgbk
lawgbk
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2021-12-24
Ok
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lawgbk
lawgbk
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2021-12-23
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U.S. adds Merck pill as 2nd easy-to-use drug against COVID-19<blockquote>美国将默克药丸列为第二种易于使用的抗 COVID-19 药物</blockquote>
U.S. health regulators on Thursday authorized the second pill against COVID-19, providing another ea
U.S. adds Merck pill as 2nd easy-to-use drug against COVID-19<blockquote>美国将默克药丸列为第二种易于使用的抗 COVID-19 药物</blockquote>
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lawgbk
lawgbk
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2021-12-22
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Allakos slumps 87%, draws analysts downgrade on 'disappointing' lirentelimab data<blockquote>Allakos 股价暴跌 87%，分析师因 lirentelimab 数据“令人失望”而下调评级</blockquote>
Allakos continues to slide, falls 87.4% premarket following yesterday's announcement that its late-s
Allakos slumps 87%, draws analysts downgrade on 'disappointing' lirentelimab data<blockquote>Allakos 股价暴跌 87%，分析师因 lirentelimab 数据“令人失望”而下调评级</blockquote>
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lawgbk
lawgbk
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2021-12-21
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lawgbk
lawgbk
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2021-12-20
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Mega-cap growth stocks extended their fall from the previous session<blockquote>大型成长股较上一交易日跌幅扩大</blockquote>
Mega-cap growth stocks extended their fall from the previous session, with Apple, Meta Platforms and
Mega-cap growth stocks extended their fall from the previous session<blockquote>大型成长股较上一交易日跌幅扩大</blockquote>
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The company acquired Red Robin and AT&T outparcel properties for $2.8 million, and Portillo’s ...</p><p><blockquote><div>Four Corners Property Trust，Inc.报告以250万美元收购了轮胎先生的三处房产。该公司以 280 万美元收购了 Red Robin 和 AT&T outparcel properties，以及 Portillo 的 ...</div></blockquote></p><p> <a href=\"https://www.benzinga.com/news/earnings/21/12/24825536/5-stocks-to-watch-for-december-30-2021\">网页链接</a> </div> </p><p><blockquote><a href=\"https://www.benzinga.com/news/earnings/21/12/24825536/5-stocks-to-watch-for-december-30-2021\">网页连接</a></blockquote></p><p></p>","source":"lsy1606299360108","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>5 Stocks To Watch For December 30, 2021<blockquote>2021 年 12 月 30 日值得关注的 5 只股票</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\n5 Stocks To Watch For December 30, 2021<blockquote>2021 年 12 月 30 日值得关注的 5 只股票</blockquote>\n</h2>\n<h4 class=\"meta\">\n<p class=\"head\">\n<strong class=\"h-name small\">Benzinga</strong><span class=\"h-time small\">2021-12-30 17:10</span>\n</p>\n</h4>\n</header>\n<article>\n<p><div> Four Corners Property Trust, Inc. reported acquisition of three Mr. Tire Properties for $2.5 million. The company acquired Red Robin and AT&T outparcel properties for $2.8 million, and Portillo’s ...</p><p><blockquote><div>Four Corners Property Trust，Inc.报告以250万美元收购了轮胎先生的三处房产。该公司以 280 万美元收购了 Red Robin 和 AT&T outparcel properties，以及 Portillo 的 ...</div></blockquote></p><p> <a href=\"https://www.benzinga.com/news/earnings/21/12/24825536/5-stocks-to-watch-for-december-30-2021\">网页链接</a> </div> </p><p><blockquote><a href=\"https://www.benzinga.com/news/earnings/21/12/24825536/5-stocks-to-watch-for-december-30-2021\">网页连接</a></blockquote></p><p></p>\n<div class=\"bt-text\">\n\n\n<p> 来源：<a href=\"https://www.benzinga.com/news/earnings/21/12/24825536/5-stocks-to-watch-for-december-30-2021\">Benzinga</a></p>\n<p>为提升您的阅读体验，我们对本页面进行了排版优化</p>\n\n\n</div>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"BIIB":"渤健公司","FCPT":"Four Corners Property Trust, Inc.","EGY":"瓦可能源"},"source_url":"https://www.benzinga.com/news/earnings/21/12/24825536/5-stocks-to-watch-for-december-30-2021","is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1194675549","content_text":"Four Corners Property Trust, Inc. reported acquisition of three Mr. Tire Properties for $2.5 million. The company acquired Red Robin and AT&T outparcel properties for $2.8 million, and Portillo’s restaurant property for $3.3 million. FCPT shares gained 1.6% to close at $29.69 on Wednesday.Biogen Inc. shares jumped over 9% on Wednesday after Korea Economic Daily reported that Samsung Group is in talks to buy the company. Biogen shares jumped 9.5% to close at $258.31 on Wednesday, adding another 0.7% in after-hours trading.VAALCO Energy, Inc. reported the filing of a $50 million shelf registration. VAALCO Energy shares fell 4.5% to $3.2001 in the after-hours trading session.TPG Pace Beneficial Finance Corp. and EVBox Group have mutually agreed to terminate their earlier announced business combination agreement. TPG Pace Beneficial Finance shares dropped 0.8% to $9.74 in the after-hours trading session.Shares of Scienjoy Holding Corporation gained more than 6% on Wednesday as the company agreed to acquire Hongle.tv for $43.8 million. Scienjoy shares rose further by 1.4% to $5.80 in the after-hours trading session.","news_type":1,"symbols_score_info":{"SJOYW":0.9,"FCPT":0.9,"BIIB":0.9,"TPGY":0.9,"EGY":0.9}},"isVote":1,"tweetType":1,"viewCount":3242,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":696781701,"gmtCreate":1640770110648,"gmtModify":1640770111134,"author":{"id":"3569580504698649","authorId":"3569580504698649","name":"lawgbk","avatar":"https://static.tigerbbs.com/aed8dcf3ce6c592dffc1e60aa40d85bc","crmLevel":12,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3569580504698649","idStr":"3569580504698649"},"themes":[],"title":"","htmlText":"Like","listText":"Like","text":"Like","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":5,"commentSize":1,"repostSize":0,"link":"https://laohu8.com/post/696781701","repostId":"1163674351","repostType":4,"repost":{"id":"1163674351","kind":"news","weMediaInfo":{"introduction":"Providing stock market headlines, business news, financials and earnings ","home_visible":1,"media_name":"Tiger Newspress","id":"1079075236","head_image":"https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba"},"pubTimestamp":1640769761,"share":"https://www.laohunote.com/m/news/1163674351?lang=zh_CN&edition=full","pubTime":"2021-12-29 17:22","market":"us","language":"en","title":"Pop Culture Group Stock Jumped 22% in Premarket Trading<blockquote>流行文化集团股价在盘前交易中上涨 22%</blockquote>","url":"https://stock-news.laohu8.com/highlight/detail?id=1163674351","media":"Tiger Newspress","summary":"Pop Culture Group stock jumped 22% in premarket trading.The stock soared nearly 36% yesterday.","content":"<p><html><head></head><body>Pop Culture Group stock jumped 22% in premarket trading.The stock soared nearly 36% yesterday.</p><p><blockquote><html><head></head><body>流行文化集团股价在盘前交易中上涨 22%。该股昨天飙升近36%。</body></html></blockquote></p><p><img src=\"https://static.tigerbbs.com/bd6f14a690cc0684dca8112f39c885a1\" tg-width=\"842\" tg-height=\"621\" referrerpolicy=\"no-referrer\"/></p><p><blockquote></blockquote></p><p></body></html></p><p><blockquote></blockquote></p><p></p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Pop Culture Group Stock Jumped 22% in Premarket Trading<blockquote>流行文化集团股价在盘前交易中上涨 22%</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; 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overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nPop Culture Group Stock Jumped 22% in Premarket Trading<blockquote>流行文化集团股价在盘前交易中上涨 22%</blockquote>\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/1079075236\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Tiger Newspress </p>\n<p class=\"h-time smaller\">2021-12-29 17:22</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<p><html><head></head><body>Pop Culture Group stock jumped 22% in premarket trading.The stock soared nearly 36% yesterday.</p><p><blockquote><html><head></head><body>流行文化集团股价在盘前交易中上涨 22%。该股昨天飙升近36%。</body></html></blockquote></p><p><img src=\"https://static.tigerbbs.com/bd6f14a690cc0684dca8112f39c885a1\" tg-width=\"842\" tg-height=\"621\" referrerpolicy=\"no-referrer\"/></p><p><blockquote></blockquote></p><p></body></html></p><p><blockquote></blockquote></p><p></p>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"CPOP":"普普文化"},"source_url":"","is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1163674351","content_text":"Pop Culture Group stock jumped 22% in premarket trading.The stock soared nearly 36% yesterday.","news_type":1,"symbols_score_info":{"CPOP":0.9}},"isVote":1,"tweetType":1,"viewCount":5114,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":696211586,"gmtCreate":1640701624348,"gmtModify":1640701699103,"author":{"id":"3569580504698649","authorId":"3569580504698649","name":"lawgbk","avatar":"https://static.tigerbbs.com/aed8dcf3ce6c592dffc1e60aa40d85bc","crmLevel":12,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3569580504698649","idStr":"3569580504698649"},"themes":[],"title":"","htmlText":"Like","listText":"Like","text":"Like","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":2,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/696211586","repostId":"1182153918","repostType":4,"repost":{"id":"1182153918","kind":"news","weMediaInfo":{"introduction":"Providing stock market headlines, business news, financials and earnings ","home_visible":1,"media_name":"Tiger Newspress","id":"1079075236","head_image":"https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba"},"pubTimestamp":1640696271,"share":"https://www.laohunote.com/m/news/1182153918?lang=zh_CN&edition=full","pubTime":"2021-12-28 20:57","market":"us","language":"en","title":"Toplines Before US Market Open on Tuesday<blockquote>周二美国市场开盘前的顶线</blockquote>","url":"https://stock-news.laohu8.com/highlight/detail?id=1182153918","media":"Tiger Newspress","summary":"The S&P 500 and Dow futures hit all-time highs on Tuesday, building on a record-setting rally amid t","content":"<p>The S&P 500 and Dow futures hit all-time highs on Tuesday, building on a record-setting rally amid thin trading volumes, with investors trying to shrug off the impact from Omicron-driven travel disruptions and store closures.</p><p><blockquote>标普500和道琼斯指数期货周二创下历史新高，在交易量清淡的情况下创纪录上涨的基础上，投资者试图摆脱 Omicron 驱动的旅行中断和商店关闭的影响。</blockquote></p><p> Apple Inc(AAPL.O) closed all of its 12 New York City stores to indoor shopping, the latest company to tighten protocols as cases surged across the United States and prompted thousands of flight cancellations for the fourth day on Monday.</p><p><blockquote>苹果公司 (AAPL.O) 关闭了其纽约市所有 12 家商店，禁止室内购物，这是最新一家收紧防疫措施的公司，因为病例在美国各地激增，并导致周一第四天取消了数千个航班。</blockquote></p><p> However, strong consumer demand trends reinstated confidence about the underlying economic strength and helped Wall Street climb for a fourth straight day on Monday. The S&P 500 and Nasdaq posted their best four-day rally since November 2020.</p><p><blockquote>然而，强劲的消费者需求趋势恢复了对潜在经济实力的信心，并帮助华尔街周一连续第四天上涨。标普500和纳斯达克公布了自2020年11月以来最好的为期四天的反弹。</blockquote></p><p> Data last week showing the Omicron variant being less deadly than feared, and new pills and more vaccines to fight COVID-19 also spurred risk appetite, putting the three main indexes on pace for monthly gains.</p><p><blockquote>上周的数据显示，奥密克戎变种的致命性没有人们担心的那么低，抗击 COVID-19 的新药和更多疫苗也刺激了风险偏好，使三大股指按月上涨。</blockquote></p><p> At 8:00 a.m. ET, Dow e-minis were up 91 points, or 0.25%, S&P 500 e-minis were up 11.75 points, or 0.25%, and Nasdaq 100 e-minis were up 77.75 points, or 0.47%. Some megacap companies have roared in the recent rally, with Apple Inc (AAPL.O) — up marginally in premarket trading — within spitting distance of becoming the first U.S. company to hit $3 trillion in market capitalization.</p><p><blockquote>美国东部时间上午 8:00，道琼斯电子迷你指数上涨 91 点，涨幅 0.25%，标普500电子迷你指数上涨 11.75 点，涨幅 0.25%，纳斯达克 100 电子迷你指数上涨 77.75 点，涨幅 0.47%。一些大型公司在最近的反弹中表现强劲，苹果公司（AAPL.O）在盘前交易中小幅上涨，距离成为第一家市值达到 3 万亿美元的美国公司仅一步之遥。</blockquote></p><p> <p class=\"t-img-caption\"><img src=\"https://static.tigerbbs.com/2529d5fc75126a96cbbc5d6e8f3ec05a\" tg-width=\"667\" tg-height=\"211\" width=\"100%\" height=\"auto\"><span>*Source From Tiger Trade, EST 08:00</span></p><p><blockquote><p class=\"t-img-caption\"><span>*来源：Tiger Trade，美国东部时间 08:00</span></p></blockquote></p><p> <b>Stocks making the biggest moves premarket: Apple, Vipshop, Coinbase and others</b></p><p><blockquote><b>盘前波动最大的股票：苹果、唯品会、Coinbase 等</b></blockquote></p><p> Apple (AAPL) – The company is once again approaching a $3 trillion market value, needing to reach $182.86 per share to achieve that milestone. Separately, Apple is closing its 12 New York City stores to indoor traffic due to the spread of the Covid-19 omicron variant. Apple edged higher by 0.3% in premarket action.</p><p><blockquote>苹果（AAPL）——该公司的市值再次接近3万亿美元，需要达到每股182.86美元才能实现这一里程碑。另外，由于 Covid-19 omicron 变种的传播，苹果正在关闭其 12 家纽约市门店，禁止室内通行。苹果在盘前交易中小幅上涨 0.3%。</blockquote></p><p> Tesla（TSLA）– Tesla has 30% upside in 2022 on China demand, Wedbush Says, and reiterates its outperform rating and $1,400 price target. Tesla stock added 1.77% in premarket.</p><p><blockquote>特斯拉（TSLA）--韦德布什表示，受中国需求的影响，特斯拉在2022年有30%的上涨空间，并重申了其跑赢大盘的评级和1400美元的目标价。特斯拉股价盘前上涨1.77%。</blockquote></p><p> Nvidia (NVDA) – The graphics chip maker’s shares added 1.2% in the premarket after rising for the past 4 days in a row and helping to lead the iShares Semiconductor ETF (SOXX) to a record high in Monday trading. Advanced Micro Devices (AMD) – also a big factor in driving the SOXX higher – added 1% in premarket trading. Chip stocks have been rising amid supply shortages and strong demand, leading to higher prices for chips.</p><p><blockquote>英伟达（NVDA）--这家图形芯片制造商的股价在过去连续4天上涨后，在盘前上涨了1.2%，并帮助iShares半导体ETF（SOXX）在周一的交易中创下历史新高。Advanced Micro Devices (AMD) 也是推动 SOXX 走高的一个重要因素，在盘前交易中上涨了 1%。在供应短缺和需求强劲的情况下，芯片库存一直在上涨，导致芯片价格上涨。</blockquote></p><p> Coinbase (COIN) – The cryptocurrency exchange operator’s shares dropped 2.2% in the premarket as the price of bitcoin retreated, putting the stock in danger of breaking a four-day win streak that saw it gain 17.7% over that stretch.</p><p><blockquote>Coinbase (COIN)--由于比特币价格回落，这家加密货币交易所运营商的股价在盘前下跌了 2.2%，这使得该股有可能打破连续四天上涨 17.7% 的局面。</blockquote></p><p> Vipshop Holdings (VIPS) – The China-based e-commerce company’s stock fell 2.4% in the premarket after cutting its current-quarter revenue guidance. Vipshop cited its “latest view on the market and operational conditions” without being specific, but a Jefferies report said warmer weather and an increase in Covid-19 cases likely dented consumer demand.</p><p><blockquote>唯品会控股（VIPS）--这家总部位于中国的电子商务公司在下调本季度营收指引后，其股价在盘前下跌了 2.4%。唯品会引用了 “对市场和运营状况的最新看法”，但没有具体说明，但杰富瑞的一份报告称，天气转暖和 Covid-19 病例增加可能会削弱消费者需求。</blockquote></p><p> R.R. Donnelley (RRD) – R.R. Donnelley slid 1.6% in premarket trading after the business communications and marketing services company disclosed an intrusion into its technical systems. Donnelley said it is investigating and is not aware of any client data being compromised.</p><p><blockquote>R.R。唐纳利（RRD）-R.R在商业通信和营销服务公司披露其技术系统遭到入侵后，唐纳利在盘前交易中下跌 1.6%。唐纳利表示，它正在调查，不知道有任何客户数据被泄露。</blockquote></p><p> Extreme Networks (EXTR) – The cloud computing company’s stock jumped 3.6% in premarket action after Needham raised its price target on the stock to $18.50 per share from $16. The stock had closed Monday at $16.03.</p><p><blockquote>Extreme Networks (EXTR) - 在 Needham 将该股目标价从每股 16 美元上调至 18.50 美元后，这家云计算公司的股价在盘前大涨 3.6%。该股周一收盘价为 16.03 美元。</blockquote></p><p> Howard Hughes (HHC) – The real estate firm has reportedly agreed to sell a controlling interest in the Bank of America Tower in Chicago to private equity firm Oak Hill Advisors for more than $1 billion, according to a Dow Jones report quoting sources familiar with the deal.</p><p><blockquote>霍华德休斯（HHC）——据道琼斯公司援引知情人士的话报道，据报道，这家房地产公司已同意以超过10亿美元的价格将芝加哥美国银行大厦的控股权出售给私募股权公司橡树山顾问公司。</blockquote></p><p></p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Toplines Before US Market Open on Tuesday<blockquote>周二美国市场开盘前的顶线</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nToplines Before US Market Open on Tuesday<blockquote>周二美国市场开盘前的顶线</blockquote>\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/1079075236\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Tiger Newspress </p>\n<p class=\"h-time smaller\">2021-12-28 20:57</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<p>The S&P 500 and Dow futures hit all-time highs on Tuesday, building on a record-setting rally amid thin trading volumes, with investors trying to shrug off the impact from Omicron-driven travel disruptions and store closures.</p><p><blockquote>标普500和道琼斯指数期货周二创下历史新高，在交易量清淡的情况下创纪录上涨的基础上，投资者试图摆脱 Omicron 驱动的旅行中断和商店关闭的影响。</blockquote></p><p> Apple Inc(AAPL.O) closed all of its 12 New York City stores to indoor shopping, the latest company to tighten protocols as cases surged across the United States and prompted thousands of flight cancellations for the fourth day on Monday.</p><p><blockquote>苹果公司 (AAPL.O) 关闭了其纽约市所有 12 家商店，禁止室内购物，这是最新一家收紧防疫措施的公司，因为病例在美国各地激增，并导致周一第四天取消了数千个航班。</blockquote></p><p> However, strong consumer demand trends reinstated confidence about the underlying economic strength and helped Wall Street climb for a fourth straight day on Monday. The S&P 500 and Nasdaq posted their best four-day rally since November 2020.</p><p><blockquote>然而，强劲的消费者需求趋势恢复了对潜在经济实力的信心，并帮助华尔街周一连续第四天上涨。标普500和纳斯达克公布了自2020年11月以来最好的为期四天的反弹。</blockquote></p><p> Data last week showing the Omicron variant being less deadly than feared, and new pills and more vaccines to fight COVID-19 also spurred risk appetite, putting the three main indexes on pace for monthly gains.</p><p><blockquote>上周的数据显示，奥密克戎变种的致命性没有人们担心的那么低，抗击 COVID-19 的新药和更多疫苗也刺激了风险偏好，使三大股指按月上涨。</blockquote></p><p> At 8:00 a.m. ET, Dow e-minis were up 91 points, or 0.25%, S&P 500 e-minis were up 11.75 points, or 0.25%, and Nasdaq 100 e-minis were up 77.75 points, or 0.47%. Some megacap companies have roared in the recent rally, with Apple Inc (AAPL.O) — up marginally in premarket trading — within spitting distance of becoming the first U.S. company to hit $3 trillion in market capitalization.</p><p><blockquote>美国东部时间上午 8:00，道琼斯电子迷你指数上涨 91 点，涨幅 0.25%，标普500电子迷你指数上涨 11.75 点，涨幅 0.25%，纳斯达克 100 电子迷你指数上涨 77.75 点，涨幅 0.47%。一些大型公司在最近的反弹中表现强劲，苹果公司（AAPL.O）在盘前交易中小幅上涨，距离成为第一家市值达到 3 万亿美元的美国公司仅一步之遥。</blockquote></p><p> <p class=\"t-img-caption\"><img src=\"https://static.tigerbbs.com/2529d5fc75126a96cbbc5d6e8f3ec05a\" tg-width=\"667\" tg-height=\"211\" width=\"100%\" height=\"auto\"><span>*Source From Tiger Trade, EST 08:00</span></p><p><blockquote><p class=\"t-img-caption\"><span>*来源：Tiger Trade，美国东部时间 08:00</span></p></blockquote></p><p> <b>Stocks making the biggest moves premarket: Apple, Vipshop, Coinbase and others</b></p><p><blockquote><b>盘前波动最大的股票：苹果、唯品会、Coinbase 等</b></blockquote></p><p> Apple (AAPL) – The company is once again approaching a $3 trillion market value, needing to reach $182.86 per share to achieve that milestone. Separately, Apple is closing its 12 New York City stores to indoor traffic due to the spread of the Covid-19 omicron variant. Apple edged higher by 0.3% in premarket action.</p><p><blockquote>苹果（AAPL）——该公司的市值再次接近3万亿美元，需要达到每股182.86美元才能实现这一里程碑。另外，由于 Covid-19 omicron 变种的传播，苹果正在关闭其 12 家纽约市门店，禁止室内通行。苹果在盘前交易中小幅上涨 0.3%。</blockquote></p><p> Tesla（TSLA）– Tesla has 30% upside in 2022 on China demand, Wedbush Says, and reiterates its outperform rating and $1,400 price target. Tesla stock added 1.77% in premarket.</p><p><blockquote>特斯拉（TSLA）--韦德布什表示，受中国需求的影响，特斯拉在2022年有30%的上涨空间，并重申了其跑赢大盘的评级和1400美元的目标价。特斯拉股价盘前上涨1.77%。</blockquote></p><p> Nvidia (NVDA) – The graphics chip maker’s shares added 1.2% in the premarket after rising for the past 4 days in a row and helping to lead the iShares Semiconductor ETF (SOXX) to a record high in Monday trading. Advanced Micro Devices (AMD) – also a big factor in driving the SOXX higher – added 1% in premarket trading. Chip stocks have been rising amid supply shortages and strong demand, leading to higher prices for chips.</p><p><blockquote>英伟达（NVDA）--这家图形芯片制造商的股价在过去连续4天上涨后，在盘前上涨了1.2%，并帮助iShares半导体ETF（SOXX）在周一的交易中创下历史新高。Advanced Micro Devices (AMD) 也是推动 SOXX 走高的一个重要因素，在盘前交易中上涨了 1%。在供应短缺和需求强劲的情况下，芯片库存一直在上涨，导致芯片价格上涨。</blockquote></p><p> Coinbase (COIN) – The cryptocurrency exchange operator’s shares dropped 2.2% in the premarket as the price of bitcoin retreated, putting the stock in danger of breaking a four-day win streak that saw it gain 17.7% over that stretch.</p><p><blockquote>Coinbase (COIN)--由于比特币价格回落，这家加密货币交易所运营商的股价在盘前下跌了 2.2%，这使得该股有可能打破连续四天上涨 17.7% 的局面。</blockquote></p><p> Vipshop Holdings (VIPS) – The China-based e-commerce company’s stock fell 2.4% in the premarket after cutting its current-quarter revenue guidance. Vipshop cited its “latest view on the market and operational conditions” without being specific, but a Jefferies report said warmer weather and an increase in Covid-19 cases likely dented consumer demand.</p><p><blockquote>唯品会控股（VIPS）--这家总部位于中国的电子商务公司在下调本季度营收指引后，其股价在盘前下跌了 2.4%。唯品会引用了 “对市场和运营状况的最新看法”，但没有具体说明，但杰富瑞的一份报告称，天气转暖和 Covid-19 病例增加可能会削弱消费者需求。</blockquote></p><p> R.R. Donnelley (RRD) – R.R. Donnelley slid 1.6% in premarket trading after the business communications and marketing services company disclosed an intrusion into its technical systems. Donnelley said it is investigating and is not aware of any client data being compromised.</p><p><blockquote>R.R。唐纳利（RRD）-R.R在商业通信和营销服务公司披露其技术系统遭到入侵后，唐纳利在盘前交易中下跌 1.6%。唐纳利表示，它正在调查，不知道有任何客户数据被泄露。</blockquote></p><p> Extreme Networks (EXTR) – The cloud computing company’s stock jumped 3.6% in premarket action after Needham raised its price target on the stock to $18.50 per share from $16. The stock had closed Monday at $16.03.</p><p><blockquote>Extreme Networks (EXTR) - 在 Needham 将该股目标价从每股 16 美元上调至 18.50 美元后，这家云计算公司的股价在盘前大涨 3.6%。该股周一收盘价为 16.03 美元。</blockquote></p><p> Howard Hughes (HHC) – The real estate firm has reportedly agreed to sell a controlling interest in the Bank of America Tower in Chicago to private equity firm Oak Hill Advisors for more than $1 billion, according to a Dow Jones report quoting sources familiar with the deal.</p><p><blockquote>霍华德休斯（HHC）——据道琼斯公司援引知情人士的话报道，据报道，这家房地产公司已同意以超过10亿美元的价格将芝加哥美国银行大厦的控股权出售给私募股权公司橡树山顾问公司。</blockquote></p><p></p>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"TSLA":"特斯拉","AMD":"美国超微公司","AAPL":"苹果","NVDA":"英伟达",".SPX":"S&P 500 Index",".DJI":"道琼斯","COIN":"Coinbase Global, Inc.",".IXIC":"NASDAQ Composite"},"is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1182153918","content_text":"The S&P 500 and Dow futures hit all-time highs on Tuesday, building on a record-setting rally amid thin trading volumes, with investors trying to shrug off the impact from Omicron-driven travel disruptions and store closures.\nApple Inc(AAPL.O) closed all of its 12 New York City stores to indoor shopping, the latest company to tighten protocols as cases surged across the United States and prompted thousands of flight cancellations for the fourth day on Monday.\nHowever, strong consumer demand trends reinstated confidence about the underlying economic strength and helped Wall Street climb for a fourth straight day on Monday. The S&P 500 and Nasdaq posted their best four-day rally since November 2020.\nData last week showing the Omicron variant being less deadly than feared, and new pills and more vaccines to fight COVID-19 also spurred risk appetite, putting the three main indexes on pace for monthly gains.\nAt 8:00 a.m. ET, Dow e-minis were up 91 points, or 0.25%, S&P 500 e-minis were up 11.75 points, or 0.25%, and Nasdaq 100 e-minis were up 77.75 points, or 0.47%. Some megacap companies have roared in the recent rally, with Apple Inc (AAPL.O) — up marginally in premarket trading — within spitting distance of becoming the first U.S. company to hit $3 trillion in market capitalization.\n*Source From Tiger Trade, EST 08:00\nStocks making the biggest moves premarket: Apple, Vipshop, Coinbase and others\nApple (AAPL) – The company is once again approaching a $3 trillion market value, needing to reach $182.86 per share to achieve that milestone. Separately, Apple is closing its 12 New York City stores to indoor traffic due to the spread of the Covid-19 omicron variant. Apple edged higher by 0.3% in premarket action.\nTesla（TSLA）– Tesla has 30% upside in 2022 on China demand, Wedbush Says, and reiterates its outperform rating and $1,400 price target. Tesla stock added 1.77% in premarket.\nNvidia (NVDA) – The graphics chip maker’s shares added 1.2% in the premarket after rising for the past 4 days in a row and helping to lead the iShares Semiconductor ETF (SOXX) to a record high in Monday trading. Advanced Micro Devices (AMD) – also a big factor in driving the SOXX higher – added 1% in premarket trading. Chip stocks have been rising amid supply shortages and strong demand, leading to higher prices for chips.\nCoinbase (COIN) – The cryptocurrency exchange operator’s shares dropped 2.2% in the premarket as the price of bitcoin retreated, putting the stock in danger of breaking a four-day win streak that saw it gain 17.7% over that stretch.\nVipshop Holdings (VIPS) – The China-based e-commerce company’s stock fell 2.4% in the premarket after cutting its current-quarter revenue guidance. Vipshop cited its “latest view on the market and operational conditions” without being specific, but a Jefferies report said warmer weather and an increase in Covid-19 cases likely dented consumer demand.\n\nR.R. Donnelley (RRD) – R.R. Donnelley slid 1.6% in premarket trading after the business communications and marketing services company disclosed an intrusion into its technical systems. Donnelley said it is investigating and is not aware of any client data being compromised.\n\nExtreme Networks (EXTR) – The cloud computing company’s stock jumped 3.6% in premarket action after Needham raised its price target on the stock to $18.50 per share from $16. The stock had closed Monday at $16.03.\n\nHoward Hughes (HHC) – The real estate firm has reportedly agreed to sell a controlling interest in the Bank of America Tower in Chicago to private equity firm Oak Hill Advisors for more than $1 billion, according to a Dow Jones report quoting sources familiar with the deal.","news_type":1,"symbols_score_info":{".IXIC":0.9,"COIN":0.9,"AMD":0.9,"AAPL":0.9,"TSLA":0.9,".SPX":0.9,"NVDA":0.9,".DJI":0.9}},"isVote":1,"tweetType":1,"viewCount":3078,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":698410261,"gmtCreate":1640489377484,"gmtModify":1640489377962,"author":{"id":"3569580504698649","authorId":"3569580504698649","name":"lawgbk","avatar":"https://static.tigerbbs.com/aed8dcf3ce6c592dffc1e60aa40d85bc","crmLevel":12,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3569580504698649","idStr":"3569580504698649"},"themes":[],"title":"","htmlText":"Like","listText":"Like","text":"Like","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":9,"commentSize":2,"repostSize":0,"link":"https://laohu8.com/post/698410261","repostId":"2193178197","repostType":4,"isVote":1,"tweetType":1,"viewCount":3730,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":698531768,"gmtCreate":1640441356898,"gmtModify":1640441357348,"author":{"id":"3569580504698649","authorId":"3569580504698649","name":"lawgbk","avatar":"https://static.tigerbbs.com/aed8dcf3ce6c592dffc1e60aa40d85bc","crmLevel":12,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3569580504698649","idStr":"3569580504698649"},"themes":[],"title":"","htmlText":"Like","listText":"Like","text":"Like","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":5,"commentSize":2,"repostSize":0,"link":"https://laohu8.com/post/698531768","repostId":"1156159690","repostType":4,"isVote":1,"tweetType":1,"viewCount":3540,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":698367005,"gmtCreate":1640307227641,"gmtModify":1640307229602,"author":{"id":"3569580504698649","authorId":"3569580504698649","name":"lawgbk","avatar":"https://static.tigerbbs.com/aed8dcf3ce6c592dffc1e60aa40d85bc","crmLevel":12,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3569580504698649","idStr":"3569580504698649"},"themes":[],"title":"","htmlText":"Ok","listText":"Ok","text":"Ok","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":2,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/698367005","repostId":"2193078140","repostType":4,"isVote":1,"tweetType":1,"viewCount":4600,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":698932820,"gmtCreate":1640273258685,"gmtModify":1640273259116,"author":{"id":"3569580504698649","authorId":"3569580504698649","name":"lawgbk","avatar":"https://static.tigerbbs.com/aed8dcf3ce6c592dffc1e60aa40d85bc","crmLevel":12,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3569580504698649","idStr":"3569580504698649"},"themes":[],"title":"","htmlText":"Like","listText":"Like","text":"Like","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":9,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/698932820","repostId":"1192623075","repostType":4,"repost":{"id":"1192623075","kind":"news","pubTimestamp":1640269891,"share":"https://www.laohunote.com/m/news/1192623075?lang=zh_CN&edition=full","pubTime":"2021-12-23 22:31","market":"us","language":"en","title":"U.S. adds Merck pill as 2nd easy-to-use drug against COVID-19<blockquote>美国将默克药丸列为第二种易于使用的抗 COVID-19 药物</blockquote>","url":"https://stock-news.laohu8.com/highlight/detail?id=1192623075","media":"SeattleTimes","summary":"U.S. health regulators on Thursday authorized the second pill against COVID-19, providing another ea","content":"<p>U.S. health regulators on Thursday authorized the second pill against COVID-19, providing another easy-to-use medication to battle the rising tide of omicron infections.</p><p><blockquote>美国卫生监管机构周四批准了第二种针对 COVID-19 的药丸，为对抗奥密克戎感染的上升浪潮提供了另一种易于使用的药物。</blockquote></p><p> The Food and Drug Administration authorization of Merck’s molnupiravir comes one day after the agency cleared a competing drug from Pfizer. That pill, Paxlovid, is likely to become the first-choice treatment against the virus, thanks to its superior benefits and milder side effects.</p><p><blockquote>在美国食品和药物管理局批准默克公司的莫努匹拉韦的前一天，该机构批准了辉瑞公司的一种竞争药物。这种名为 Paxlovid 的药丸很可能成为对抗病毒的首选治疗方法，这要归功于其卓越的益处和较轻的副作用。</blockquote></p><p> As a result, Merck’s pill is expected to have a smaller role against the pandemic than predicted just a few weeks ago. Its ability to head off severe COVID-19 is much smaller than initially announced and the drug label will warn of serious safety issues, including the potential for birth defects.</p><p><blockquote>因此，默克公司的药丸预计在对抗大流行病方面的作用将小于几周前的预测。它阻止严重 COVID-19 的能力比最初宣布的要小得多，而且药物标签将警告严重的安全问题，包括潜在的出生缺陷。</blockquote></p><p> The Food and Drug Administration authorized Merck’s drug for adults with early symptoms of COVID-19 who face the highest risks of hospitalization, including older people and those with conditions like obesity and heart disease. The U.K. first authorized the pill in early November.</p><p><blockquote>美国食品和药物管理局批准默克公司的药物用于出现 COVID-19 早期症状、住院风险最高的成年人，包括老年人和患有肥胖症和心脏病等疾病的人。英国于 11 月初首次批准了这种药丸。</blockquote></p><p> Known as molnupiravir, the Merck drug will carry a warning against use during pregnancy. Women of childbearing age should use birth control during treatment and for a few days after while men should use birth control for at least three months after their final dose, the FDA said.</p><p><blockquote>默克公司的这种药物被称为molnupiravir，将带有怀孕期间禁止使用的警告。FDA表示，育龄妇女应在治疗期间和治疗后的几天内使用避孕措施，而男性应在最后一剂后至少三个月内使用避孕措施。</blockquote></p><p> The restrictions were expected after an FDA advisory panel only narrowly endorsed the drug last month, warning that its use would have to be strictly tailored to patients who can benefit the most.</p><p><blockquote>FDA 顾问小组上个月仅以微弱优势批准了该药物，并警告说，该药物的使用必须严格针对最能受益的患者，因此这些限制是意料之中的。</blockquote></p><p> The Pfizer pill works differently and doesn’t carry the same risks. Additionally, Pfizer’s drug was roughly three times more effective in testing, reducing hospitalization and death by nearly 90% among high-risk patients, compared with 30% for Merck’s.</p><p><blockquote>辉瑞公司的药丸作用不同，风险也不同。此外，辉瑞公司的药物在检测中的有效性约为三倍，将高危患者的住院和死亡率降低了近 90%，而默克公司的住院和死亡率降低了 30%。</blockquote></p><p> Some experts question whether there will be much of a role for the Merck drug in the U.S.</p><p><blockquote>一些专家质疑默克药物在美国是否会发挥很大作用。</blockquote></p><p> “To the extent that there’s an ample supply of Pfizer’s pill, I think it won’t be used,” said Dr. Gregory Poland of the Mayo Clinic, referring to the Merck drug. “There would be no reason, given it has less efficacy and a higher risk of side effects.”</p><p><blockquote>“梅奥诊所的格雷戈里-波兰（Gregory Poland）博士在谈到默克公司的药物时说：”只要辉瑞公司的药片供应充足，我认为它就不会被使用。“没有理由这样做，因为它的疗效较差，副作用风险较高。”</blockquote></p><p> For now, the FDA decision provides another potential option against the virus that has killed more than 800,000 Americans, even as health officials brace for record-setting cases, hospitalizations and deaths driven by the omicron variant. Antiviral pills, including Merck’s, are expected to be effective against omicron because they don’t target the spike protein where most of the variant’s worrisome mutations reside.</p><p><blockquote>目前，FDA 的决定为对抗这种已导致超过 80 万美国人死亡的病毒提供了另一个潜在选择，尽管卫生官员正在为奥密克戎变种导致的创纪录的病例、住院和死亡做好准备。包括默克公司在内的抗病毒药丸有望对奥密克戎病毒有效，因为它们不针对刺突蛋白，而刺突蛋白是该变种病毒大部分令人担忧的突变所在。</blockquote></p><p> The FDA based its decision on results showing nearly 7% of patients taking the drug ended up in the hospital and one died at the end of 30 days. That compared with 10% of patients hospitalized who were taking the placebo and nine deaths.</p><p><blockquote>FDA 的决定是基于结果显示，近 7% 服用该药物的患者最终住院，一名患者在 30 天后死亡。相比之下，10%的住院患者服用安慰剂，9人死亡。</blockquote></p><p> Federal officials have agreed to purchase enough of the drug to treat 3.1 million people.</p><p><blockquote>联邦官员已经同意购买足够的药物来治疗310万人。</blockquote></p><p> The U.S. will pay about $700 for each course of Merck’s drug, which requires patients to take four pills twice a day for five days. A review by Harvard University and King’s College London estimated it costs about $18 to make each 40-pill course of treatment.</p><p><blockquote>美国将为默克公司的每个疗程支付约 700 美元，该疗程要求患者每天服用两次，每次四片，连续服用五天。哈佛大学和伦敦国王学院的一项审查估计，每个 40 粒疗程的治疗费用约为 18 美元。</blockquote></p><p> Merck’s drug inserts tiny errors into the coronavirus’ genetic code to slow its reproduction. That genetic effect has raised concerns that the drug could cause mutations in human fetuses and even spur more virulent strains of the virus. But FDA scientists said the variant risk is largely theoretical because people take the drug for such a short period of time.</p><p><blockquote>默克公司的药物在冠状病毒的遗传密码中插入微小错误，以减缓其繁殖速度。这种遗传效应引发了人们的担忧，即这种药物可能会导致人类胎儿发生突变，甚至刺激更具毒性的病毒株。但FDA科学家表示，变异风险在很大程度上是理论上的，因为人们服用这种药物的时间很短。</blockquote></p><p></p>","source":"lsy1640271591192","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>U.S. adds Merck pill as 2nd easy-to-use drug against COVID-19<blockquote>美国将默克药丸列为第二种易于使用的抗 COVID-19 药物</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nU.S. adds Merck pill as 2nd easy-to-use drug against COVID-19<blockquote>美国将默克药丸列为第二种易于使用的抗 COVID-19 药物</blockquote>\n</h2>\n<h4 class=\"meta\">\n<p class=\"head\">\n<strong class=\"h-name small\">SeattleTimes</strong><span class=\"h-time small\">2021-12-23 22:31</span>\n</p>\n</h4>\n</header>\n<article>\n<p>U.S. health regulators on Thursday authorized the second pill against COVID-19, providing another easy-to-use medication to battle the rising tide of omicron infections.</p><p><blockquote>美国卫生监管机构周四批准了第二种针对 COVID-19 的药丸，为对抗奥密克戎感染的上升浪潮提供了另一种易于使用的药物。</blockquote></p><p> The Food and Drug Administration authorization of Merck’s molnupiravir comes one day after the agency cleared a competing drug from Pfizer. That pill, Paxlovid, is likely to become the first-choice treatment against the virus, thanks to its superior benefits and milder side effects.</p><p><blockquote>在美国食品和药物管理局批准默克公司的莫努匹拉韦的前一天，该机构批准了辉瑞公司的一种竞争药物。这种名为 Paxlovid 的药丸很可能成为对抗病毒的首选治疗方法，这要归功于其卓越的益处和较轻的副作用。</blockquote></p><p> As a result, Merck’s pill is expected to have a smaller role against the pandemic than predicted just a few weeks ago. Its ability to head off severe COVID-19 is much smaller than initially announced and the drug label will warn of serious safety issues, including the potential for birth defects.</p><p><blockquote>因此，默克公司的药丸预计在对抗大流行病方面的作用将小于几周前的预测。它阻止严重 COVID-19 的能力比最初宣布的要小得多，而且药物标签将警告严重的安全问题，包括潜在的出生缺陷。</blockquote></p><p> The Food and Drug Administration authorized Merck’s drug for adults with early symptoms of COVID-19 who face the highest risks of hospitalization, including older people and those with conditions like obesity and heart disease. The U.K. first authorized the pill in early November.</p><p><blockquote>美国食品和药物管理局批准默克公司的药物用于出现 COVID-19 早期症状、住院风险最高的成年人，包括老年人和患有肥胖症和心脏病等疾病的人。英国于 11 月初首次批准了这种药丸。</blockquote></p><p> Known as molnupiravir, the Merck drug will carry a warning against use during pregnancy. Women of childbearing age should use birth control during treatment and for a few days after while men should use birth control for at least three months after their final dose, the FDA said.</p><p><blockquote>默克公司的这种药物被称为molnupiravir，将带有怀孕期间禁止使用的警告。FDA表示，育龄妇女应在治疗期间和治疗后的几天内使用避孕措施，而男性应在最后一剂后至少三个月内使用避孕措施。</blockquote></p><p> The restrictions were expected after an FDA advisory panel only narrowly endorsed the drug last month, warning that its use would have to be strictly tailored to patients who can benefit the most.</p><p><blockquote>FDA 顾问小组上个月仅以微弱优势批准了该药物，并警告说，该药物的使用必须严格针对最能受益的患者，因此这些限制是意料之中的。</blockquote></p><p> The Pfizer pill works differently and doesn’t carry the same risks. Additionally, Pfizer’s drug was roughly three times more effective in testing, reducing hospitalization and death by nearly 90% among high-risk patients, compared with 30% for Merck’s.</p><p><blockquote>辉瑞公司的药丸作用不同，风险也不同。此外，辉瑞公司的药物在检测中的有效性约为三倍，将高危患者的住院和死亡率降低了近 90%，而默克公司的住院和死亡率降低了 30%。</blockquote></p><p> Some experts question whether there will be much of a role for the Merck drug in the U.S.</p><p><blockquote>一些专家质疑默克药物在美国是否会发挥很大作用。</blockquote></p><p> “To the extent that there’s an ample supply of Pfizer’s pill, I think it won’t be used,” said Dr. Gregory Poland of the Mayo Clinic, referring to the Merck drug. “There would be no reason, given it has less efficacy and a higher risk of side effects.”</p><p><blockquote>“梅奥诊所的格雷戈里-波兰（Gregory Poland）博士在谈到默克公司的药物时说：”只要辉瑞公司的药片供应充足，我认为它就不会被使用。“没有理由这样做，因为它的疗效较差，副作用风险较高。”</blockquote></p><p> For now, the FDA decision provides another potential option against the virus that has killed more than 800,000 Americans, even as health officials brace for record-setting cases, hospitalizations and deaths driven by the omicron variant. Antiviral pills, including Merck’s, are expected to be effective against omicron because they don’t target the spike protein where most of the variant’s worrisome mutations reside.</p><p><blockquote>目前，FDA 的决定为对抗这种已导致超过 80 万美国人死亡的病毒提供了另一个潜在选择，尽管卫生官员正在为奥密克戎变种导致的创纪录的病例、住院和死亡做好准备。包括默克公司在内的抗病毒药丸有望对奥密克戎病毒有效，因为它们不针对刺突蛋白，而刺突蛋白是该变种病毒大部分令人担忧的突变所在。</blockquote></p><p> The FDA based its decision on results showing nearly 7% of patients taking the drug ended up in the hospital and one died at the end of 30 days. That compared with 10% of patients hospitalized who were taking the placebo and nine deaths.</p><p><blockquote>FDA 的决定是基于结果显示，近 7% 服用该药物的患者最终住院，一名患者在 30 天后死亡。相比之下，10%的住院患者服用安慰剂，9人死亡。</blockquote></p><p> Federal officials have agreed to purchase enough of the drug to treat 3.1 million people.</p><p><blockquote>联邦官员已经同意购买足够的药物来治疗310万人。</blockquote></p><p> The U.S. will pay about $700 for each course of Merck’s drug, which requires patients to take four pills twice a day for five days. A review by Harvard University and King’s College London estimated it costs about $18 to make each 40-pill course of treatment.</p><p><blockquote>美国将为默克公司的每个疗程支付约 700 美元，该疗程要求患者每天服用两次，每次四片，连续服用五天。哈佛大学和伦敦国王学院的一项审查估计，每个 40 粒疗程的治疗费用约为 18 美元。</blockquote></p><p> Merck’s drug inserts tiny errors into the coronavirus’ genetic code to slow its reproduction. That genetic effect has raised concerns that the drug could cause mutations in human fetuses and even spur more virulent strains of the virus. But FDA scientists said the variant risk is largely theoretical because people take the drug for such a short period of time.</p><p><blockquote>默克公司的药物在冠状病毒的遗传密码中插入微小错误，以减缓其繁殖速度。这种遗传效应引发了人们的担忧，即这种药物可能会导致人类胎儿发生突变，甚至刺激更具毒性的病毒株。但FDA科学家表示，变异风险在很大程度上是理论上的，因为人们服用这种药物的时间很短。</blockquote></p><p></p>\n<div class=\"bt-text\">\n\n\n<p> 来源：<a href=\"https://www.seattletimes.com/business/us-adds-merck-pill-as-2nd-easy-to-use-drug-against-covid-19/\">SeattleTimes</a></p>\n<p>为提升您的阅读体验，我们对本页面进行了排版优化</p>\n\n\n</div>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"PFE":"辉瑞","MRK":"默沙东"},"source_url":"https://www.seattletimes.com/business/us-adds-merck-pill-as-2nd-easy-to-use-drug-against-covid-19/","is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1192623075","content_text":"U.S. health regulators on Thursday authorized the second pill against COVID-19, providing another easy-to-use medication to battle the rising tide of omicron infections.\nThe Food and Drug Administration authorization of Merck’s molnupiravir comes one day after the agency cleared a competing drug from Pfizer. That pill, Paxlovid, is likely to become the first-choice treatment against the virus, thanks to its superior benefits and milder side effects.\nAs a result, Merck’s pill is expected to have a smaller role against the pandemic than predicted just a few weeks ago. Its ability to head off severe COVID-19 is much smaller than initially announced and the drug label will warn of serious safety issues, including the potential for birth defects.\nThe Food and Drug Administration authorized Merck’s drug for adults with early symptoms of COVID-19 who face the highest risks of hospitalization, including older people and those with conditions like obesity and heart disease. The U.K. first authorized the pill in early November.\nKnown as molnupiravir, the Merck drug will carry a warning against use during pregnancy. Women of childbearing age should use birth control during treatment and for a few days after while men should use birth control for at least three months after their final dose, the FDA said.\nThe restrictions were expected after an FDA advisory panel only narrowly endorsed the drug last month, warning that its use would have to be strictly tailored to patients who can benefit the most.\nThe Pfizer pill works differently and doesn’t carry the same risks. Additionally, Pfizer’s drug was roughly three times more effective in testing, reducing hospitalization and death by nearly 90% among high-risk patients, compared with 30% for Merck’s.\nSome experts question whether there will be much of a role for the Merck drug in the U.S.\n“To the extent that there’s an ample supply of Pfizer’s pill, I think it won’t be used,” said Dr. Gregory Poland of the Mayo Clinic, referring to the Merck drug. “There would be no reason, given it has less efficacy and a higher risk of side effects.”\nFor now, the FDA decision provides another potential option against the virus that has killed more than 800,000 Americans, even as health officials brace for record-setting cases, hospitalizations and deaths driven by the omicron variant. Antiviral pills, including Merck’s, are expected to be effective against omicron because they don’t target the spike protein where most of the variant’s worrisome mutations reside.\nThe FDA based its decision on results showing nearly 7% of patients taking the drug ended up in the hospital and one died at the end of 30 days. That compared with 10% of patients hospitalized who were taking the placebo and nine deaths.\nFederal officials have agreed to purchase enough of the drug to treat 3.1 million people.\nThe U.S. will pay about $700 for each course of Merck’s drug, which requires patients to take four pills twice a day for five days. A review by Harvard University and King’s College London estimated it costs about $18 to make each 40-pill course of treatment.\nMerck’s drug inserts tiny errors into the coronavirus’ genetic code to slow its reproduction. That genetic effect has raised concerns that the drug could cause mutations in human fetuses and even spur more virulent strains of the virus. But FDA scientists said the variant risk is largely theoretical because people take the drug for such a short period of time.","news_type":1,"symbols_score_info":{"MRK":0.9,"PFE":0.9}},"isVote":1,"tweetType":1,"viewCount":4859,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":691616001,"gmtCreate":1640182784825,"gmtModify":1640183347066,"author":{"id":"3569580504698649","authorId":"3569580504698649","name":"lawgbk","avatar":"https://static.tigerbbs.com/aed8dcf3ce6c592dffc1e60aa40d85bc","crmLevel":12,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3569580504698649","idStr":"3569580504698649"},"themes":[],"title":"","htmlText":"Like","listText":"Like","text":"Like","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":4,"commentSize":1,"repostSize":0,"link":"https://laohu8.com/post/691616001","repostId":"1163953446","repostType":4,"repost":{"id":"1163953446","kind":"news","weMediaInfo":{"introduction":"Providing stock market headlines, business news, financials and earnings ","home_visible":1,"media_name":"Tiger Newspress","id":"1079075236","head_image":"https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba"},"pubTimestamp":1640182473,"share":"https://www.laohunote.com/m/news/1163953446?lang=zh_CN&edition=full","pubTime":"2021-12-22 22:14","market":"us","language":"en","title":"Allakos slumps 87%, draws analysts downgrade on 'disappointing' lirentelimab data<blockquote>Allakos 股价暴跌 87%，分析师因 lirentelimab 数据“令人失望”而下调评级</blockquote>","url":"https://stock-news.laohu8.com/highlight/detail?id=1163953446","media":"Tiger Newspress","summary":"Allakos continues to slide, falls 87.4% premarket following yesterday's announcement that its late-s","content":"<p>Allakos continues to slide, falls 87.4% premarket following yesterday's announcement that its late-stage studies, KRYPTOS and ENIGMA 2failed to achieve statistical significance.</p><p><blockquote>Allakos 继续下滑，盘前下跌 87.4%，此前昨天宣布其后期研究 KRYPTOS 和 ENIGMA 2 未能达到统计显著性。</blockquote></p><p> <img src=\"https://static.tigerbbs.com/961eae374dfe4dd479394caaf470012c\" tg-width=\"714\" tg-height=\"590\" width=\"100%\" height=\"auto\"></p><p><blockquote></blockquote></p><p> The studies met their histologic co-primary endpoints but failed to achieve symptomatic endpoints.</p><p><blockquote>这些研究符合其组织学共同主要终点，但未能达到症状终点。</blockquote></p><p> In ENIGMA, patients treated with lirentelimab achieved a 10.0-point reduction in Total Symptom Score-6 (TSS-6) at weeks 23-24 from baseline (baseline = 29.5) compared to an 11.5-point reduction in the placebo group (baseline = 27.7; p=0.343).</p><p><blockquote>在ENIGMA中，接受lirentelimab治疗的患者在第23-24周的总症状评分-6（TSS-6）较基线降低了10.0分（基线=29.5），而安慰剂组降低了11.5分（基线=27.7；p=0.343）。</blockquote></p><p> On the second co-primary endpoint of absolute mean change in patient reported Dysphagia Symptom Questionnaire in KRYPTOS trial, the high-dose group achieved a 17.4-point reduction, the low-dose group achieved an 11.9-point reduction and placebo achieved a 14.6-point reduction.</p><p><blockquote>在KRYPTOS试验中患者报告的吞咽困难症状问卷绝对平均变化的第二个共同主要终点上，高剂量组实现了17.4分的降低，低剂量组实现了11.9分的降低，安慰剂实现了14.6分的降低。</blockquote></p><p> Following this disappointing result, several analysts lowered their ratings of the stock and slashed the price targets.</p><p><blockquote>在这一令人失望的结果之后，几位分析师下调了该股的评级并大幅下调了目标价。</blockquote></p><p> William Blair downgraded the stock to Market Perform from Outperform.</p><p><blockquote>威廉·布莱尔将该股评级从跑赢大盘下调至大盘。</blockquote></p><p> Analysts of the firm say, \"while we believe lirentelimab has shown clear evidence of histologic activity against eosinophils and mast cells, the failure to achieve co-primary endpoints of patient reported symptoms in both studies raises questions about whether these histologic improvements can translate into clinical improvements.\"</p><p><blockquote>该公司分析师表示，“虽然我们相信lirentelimab已显示出针对嗜酸性粒细胞和肥大细胞的组织学活性的明确证据，但在两项研究中未能达到患者报告症状的共同主要终点，这引发了人们对这些组织学改善是否可以转化为临床改善的疑问。”</blockquote></p><p> With lirentelimab performing worse than placebo, there are clearly questions as to why the clean results in Phase II didn’t translate, the analyst notes.</p><p><blockquote>分析师指出，由于 lirentelimab 的表现不如安慰剂，显然存在一个问题，即为什么 II 期的干净结果没有转化。</blockquote></p><p> Cowen analyst Joseph Thome has also cut the recommendation on Allakos to Market Perform from Outperform without the price target (PT) pending pipeline clarity.</p><p><blockquote>Cowen 分析师 Joseph Thome 还将 Allakos 的建议从跑赢大盘下调至市场表现，但目标价 (PT) 尚待管道明朗。</blockquote></p><p> SVB Leerink analyst Thomas Smith downgraded the stock to Market Perform from Outperform, with PT of $17.</p><p><blockquote>SVB Leerink 分析师 Thomas Smith 将该股评级从跑赢大盘下调至大盘，PT 为 17 美元。</blockquote></p><p> Barclays analyst Carter Gould lowered the firm's PT on Allakos to $8 from $36 and keeps an Underweight rating. The company's lead asset failed in key Phase 3 studies, Gould tells investors in a research note. He views this as the \"end game\" for lirentelimab.</p><p><blockquote>巴克莱银行分析师 Carter Gould 将该公司对 Allakos 的市盈率从 36 美元下调至 8 美元，并维持跑输大盘评级。古尔德在一份研究报告中告诉投资者，该公司的主要资产在关键的第三阶段研究中失败。他认为这是lirentelimab的“终局”。</blockquote></p><p> Morgan Stanley says Allakos' disappointing data increase eosinophilic gastrointestinal diseases (EGIDs) uncertainty.</p><p><blockquote>摩根士丹利表示，Allakos 令人失望的数据增加了嗜酸性粒细胞性胃肠道疾病 (EGIDs) 的不确定性。</blockquote></p><p> Jefferies analyst Maury Raycroft cut the recommendation on Allakos to Hold from Buy.</p><p><blockquote>Jefferies 分析师 Maury Raycroft 将 Allakos 的评级从“买入”下调至“持有”。</blockquote></p><p> LifeSci Capital analyst Samuel Slutsky downgraded the stock to Market Perform from Outperform.</p><p><blockquote>LifeSci Capital 分析师 Samuel Slutsky 将该股评级从跑赢大盘下调至大盘。</blockquote></p><p></p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Allakos slumps 87%, draws analysts downgrade on 'disappointing' lirentelimab data<blockquote>Allakos 股价暴跌 87%，分析师因 lirentelimab 数据“令人失望”而下调评级</blockquote></title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; 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}\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nAllakos slumps 87%, draws analysts downgrade on 'disappointing' lirentelimab data<blockquote>Allakos 股价暴跌 87%，分析师因 lirentelimab 数据“令人失望”而下调评级</blockquote>\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/1079075236\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Tiger Newspress </p>\n<p class=\"h-time smaller\">2021-12-22 22:14</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<p>Allakos continues to slide, falls 87.4% premarket following yesterday's announcement that its late-stage studies, KRYPTOS and ENIGMA 2failed to achieve statistical significance.</p><p><blockquote>Allakos 继续下滑，盘前下跌 87.4%，此前昨天宣布其后期研究 KRYPTOS 和 ENIGMA 2 未能达到统计显著性。</blockquote></p><p> <img src=\"https://static.tigerbbs.com/961eae374dfe4dd479394caaf470012c\" tg-width=\"714\" tg-height=\"590\" width=\"100%\" height=\"auto\"></p><p><blockquote></blockquote></p><p> The studies met their histologic co-primary endpoints but failed to achieve symptomatic endpoints.</p><p><blockquote>这些研究符合其组织学共同主要终点，但未能达到症状终点。</blockquote></p><p> In ENIGMA, patients treated with lirentelimab achieved a 10.0-point reduction in Total Symptom Score-6 (TSS-6) at weeks 23-24 from baseline (baseline = 29.5) compared to an 11.5-point reduction in the placebo group (baseline = 27.7; p=0.343).</p><p><blockquote>在ENIGMA中，接受lirentelimab治疗的患者在第23-24周的总症状评分-6（TSS-6）较基线降低了10.0分（基线=29.5），而安慰剂组降低了11.5分（基线=27.7；p=0.343）。</blockquote></p><p> On the second co-primary endpoint of absolute mean change in patient reported Dysphagia Symptom Questionnaire in KRYPTOS trial, the high-dose group achieved a 17.4-point reduction, the low-dose group achieved an 11.9-point reduction and placebo achieved a 14.6-point reduction.</p><p><blockquote>在KRYPTOS试验中患者报告的吞咽困难症状问卷绝对平均变化的第二个共同主要终点上，高剂量组实现了17.4分的降低，低剂量组实现了11.9分的降低，安慰剂实现了14.6分的降低。</blockquote></p><p> Following this disappointing result, several analysts lowered their ratings of the stock and slashed the price targets.</p><p><blockquote>在这一令人失望的结果之后，几位分析师下调了该股的评级并大幅下调了目标价。</blockquote></p><p> William Blair downgraded the stock to Market Perform from Outperform.</p><p><blockquote>威廉·布莱尔将该股评级从跑赢大盘下调至大盘。</blockquote></p><p> Analysts of the firm say, \"while we believe lirentelimab has shown clear evidence of histologic activity against eosinophils and mast cells, the failure to achieve co-primary endpoints of patient reported symptoms in both studies raises questions about whether these histologic improvements can translate into clinical improvements.\"</p><p><blockquote>该公司分析师表示，“虽然我们相信lirentelimab已显示出针对嗜酸性粒细胞和肥大细胞的组织学活性的明确证据，但在两项研究中未能达到患者报告症状的共同主要终点，这引发了人们对这些组织学改善是否可以转化为临床改善的疑问。”</blockquote></p><p> With lirentelimab performing worse than placebo, there are clearly questions as to why the clean results in Phase II didn’t translate, the analyst notes.</p><p><blockquote>分析师指出，由于 lirentelimab 的表现不如安慰剂，显然存在一个问题，即为什么 II 期的干净结果没有转化。</blockquote></p><p> Cowen analyst Joseph Thome has also cut the recommendation on Allakos to Market Perform from Outperform without the price target (PT) pending pipeline clarity.</p><p><blockquote>Cowen 分析师 Joseph Thome 还将 Allakos 的建议从跑赢大盘下调至市场表现，但目标价 (PT) 尚待管道明朗。</blockquote></p><p> SVB Leerink analyst Thomas Smith downgraded the stock to Market Perform from Outperform, with PT of $17.</p><p><blockquote>SVB Leerink 分析师 Thomas Smith 将该股评级从跑赢大盘下调至大盘，PT 为 17 美元。</blockquote></p><p> Barclays analyst Carter Gould lowered the firm's PT on Allakos to $8 from $36 and keeps an Underweight rating. The company's lead asset failed in key Phase 3 studies, Gould tells investors in a research note. He views this as the \"end game\" for lirentelimab.</p><p><blockquote>巴克莱银行分析师 Carter Gould 将该公司对 Allakos 的市盈率从 36 美元下调至 8 美元，并维持跑输大盘评级。古尔德在一份研究报告中告诉投资者，该公司的主要资产在关键的第三阶段研究中失败。他认为这是lirentelimab的“终局”。</blockquote></p><p> Morgan Stanley says Allakos' disappointing data increase eosinophilic gastrointestinal diseases (EGIDs) uncertainty.</p><p><blockquote>摩根士丹利表示，Allakos 令人失望的数据增加了嗜酸性粒细胞性胃肠道疾病 (EGIDs) 的不确定性。</blockquote></p><p> Jefferies analyst Maury Raycroft cut the recommendation on Allakos to Hold from Buy.</p><p><blockquote>Jefferies 分析师 Maury Raycroft 将 Allakos 的评级从“买入”下调至“持有”。</blockquote></p><p> LifeSci Capital analyst Samuel Slutsky downgraded the stock to Market Perform from Outperform.</p><p><blockquote>LifeSci Capital 分析师 Samuel Slutsky 将该股评级从跑赢大盘下调至大盘。</blockquote></p><p></p>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{},"is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1163953446","content_text":"Allakos continues to slide, falls 87.4% premarket following yesterday's announcement that its late-stage studies, KRYPTOS and ENIGMA 2failed to achieve statistical significance.\n\nThe studies met their histologic co-primary endpoints but failed to achieve symptomatic endpoints.\nIn ENIGMA, patients treated with lirentelimab achieved a 10.0-point reduction in Total Symptom Score-6 (TSS-6) at weeks 23-24 from baseline (baseline = 29.5) compared to an 11.5-point reduction in the placebo group (baseline = 27.7; p=0.343).\nOn the second co-primary endpoint of absolute mean change in patient reported Dysphagia Symptom Questionnaire in KRYPTOS trial, the high-dose group achieved a 17.4-point reduction, the low-dose group achieved an 11.9-point reduction and placebo achieved a 14.6-point reduction.\nFollowing this disappointing result, several analysts lowered their ratings of the stock and slashed the price targets.\nWilliam Blair downgraded the stock to Market Perform from Outperform.\nAnalysts of the firm say, \"while we believe lirentelimab has shown clear evidence of histologic activity against eosinophils and mast cells, the failure to achieve co-primary endpoints of patient reported symptoms in both studies raises questions about whether these histologic improvements can translate into clinical improvements.\"\nWith lirentelimab performing worse than placebo, there are clearly questions as to why the clean results in Phase II didn’t translate, the analyst notes.\nCowen analyst Joseph Thome has also cut the recommendation on Allakos to Market Perform from Outperform without the price target (PT) pending pipeline clarity.\nSVB Leerink analyst Thomas Smith downgraded the stock to Market Perform from Outperform, with PT of $17.\nBarclays analyst Carter Gould lowered the firm's PT on Allakos to $8 from $36 and keeps an Underweight rating. The company's lead asset failed in key Phase 3 studies, Gould tells investors in a research note. He views this as the \"end game\" for lirentelimab.\nMorgan Stanley says Allakos' disappointing data increase eosinophilic gastrointestinal diseases (EGIDs) uncertainty.\nJefferies analyst Maury Raycroft cut the recommendation on Allakos to Hold from Buy.\nLifeSci Capital analyst Samuel Slutsky downgraded the stock to Market Perform from Outperform.","news_type":1,"symbols_score_info":{"ALLK":0.9}},"isVote":1,"tweetType":1,"viewCount":3203,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":691020559,"gmtCreate":1640099586062,"gmtModify":1640099586537,"author":{"id":"3569580504698649","authorId":"3569580504698649","name":"lawgbk","avatar":"https://static.tigerbbs.com/aed8dcf3ce6c592dffc1e60aa40d85bc","crmLevel":12,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3569580504698649","idStr":"3569580504698649"},"themes":[],"title":"","htmlText":"Like","listText":"Like","text":"Like","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":4,"commentSize":1,"repostSize":0,"link":"https://laohu8.com/post/691020559","repostId":"2193154031","repostType":4,"isVote":1,"tweetType":1,"viewCount":3884,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":693634400,"gmtCreate":1640012111093,"gmtModify":1640012111573,"author":{"id":"3569580504698649","authorId":"3569580504698649","name":"lawgbk","avatar":"https://static.tigerbbs.com/aed8dcf3ce6c592dffc1e60aa40d85bc","crmLevel":12,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3569580504698649","idStr":"3569580504698649"},"themes":[],"title":"","htmlText":"Like","listText":"Like","text":"Like","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":7,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/693634400","repostId":"1115322314","repostType":4,"repost":{"id":"1115322314","kind":"news","weMediaInfo":{"introduction":"Providing stock market headlines, business news, financials and earnings ","home_visible":1,"media_name":"Tiger Newspress","id":"1079075236","head_image":"https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba"},"pubTimestamp":1640011665,"share":"https://www.laohunote.com/m/news/1115322314?lang=zh_CN&edition=full","pubTime":"2021-12-20 22:47","market":"us","language":"en","title":"Mega-cap growth stocks extended their fall from the previous session<blockquote>大型成长股较上一交易日跌幅扩大</blockquote>","url":"https://stock-news.laohu8.com/highlight/detail?id=1115322314","media":"Tiger Newspress","summary":"Mega-cap growth stocks extended their fall from the previous session, with Apple, Meta Platforms and","content":"<p>Mega-cap growth stocks extended their fall from the previous session, with Apple, Meta Platforms and Microsoft Corp down between 1% and 3%.</p><p><blockquote>大型成长股延续了前一交易日的跌幅，苹果、Meta Platforms 和微软公司下跌 1% 至 3%。</blockquote></p><p> <img src=\"https://static.tigerbbs.com/bcbe2eb85bd02485d4f915039e5a7c33\" tg-width=\"709\" tg-height=\"607\" referrerpolicy=\"no-referrer\"></p><p><blockquote></blockquote></p><p></p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; 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